- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis
of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell
compensation for insulin resistance, consideration is also given to the mechanisms ... Cited by 199 - Related articles - BL Direct - All 7 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that are proposed
to play a role in all forms of type 2 diabetes. The underlying concept is that once the primary pathogenesis
of diabetes is established, probably involving both genetic and environmental forces, ... Cited by 71 - Related articles - BL Direct - All 7 versions
- ►endojournals.org A Wiederkehr, CB Wollheim - Endocrinology, 2006 - Endocrine Soc Mitochondria are essential for intermediary metabolism as well as energy production in the
cell. Their aerobic metabolism permits oxidation of glucose and fatty acids for the generation
of ATP and other intermediates that are exchanged with the cytoplasm for various ... Cited by 55 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Vaxillaire, J Veslot, C Dina, C Proença, S Cauchi, G … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— The GCK (Glucokinase) −30A allele was associated with increased type 2 diabetes
risk at the end of the follow-up study (adjusted OR 1.34 [95% CI 1.07–1.69]) under an additive
model, as supported in independent French diabetic case subjects (OR 1.22, P = 0.007), ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Maedler, DM Schumann, N Sauter, H Ellingsgaard, D … - Diabetes, 2006 - Am Diabetes Assoc High glucose concentrations have a dual effect on β-cell turnover, inducing proliferation in the
short-term and apoptosis in the long-term. Hyperglycemia leads to β-cell production of interleuking
(IL)-1β in human pancreatic islets. Fas, a death receptor regulated by IL-1β, is involved in ... Cited by 31 - Related articles - BL Direct - All 4 versions
R Mussmann, M Geese, F Harder, S Kegel, U … - Journal of Biological …, 2007 - ASBMB Recent developments indicate that the regeneration of beta cell function and mass in patients
with diabetes is possible. A regenerative approach may represent an alternative treatment option
relative to current diabetes therapies that fail to provide optimal glycemic control. Here we ... Cited by 30 - Related articles - All 7 versions
M Prentki, CJ Nolan - 临床研究杂志, 2006 - journal.shouxi.net The major focus of this Review is on the mechanisms of islet ? cell failure in the pathogenesis
of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of ? cell
compensation for insulin resistance, consideration is also given to the mechanisms ... Cited by 31 - Related articles - Cached - All 2 versions
YM Go, DP Jones - BBA-General Subjects, 2008 - Elsevier Diverse functions of eukaryotic cells are optimized by organization of compatible chemistries
into distinct compartments defined by the structures of lipid-containing membranes, multiprotein
complexes and oligomeric structures of saccharides and nucleic acids. This structural and ... Cited by 27 - Related articles - All 2 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N Billestrup, T … - Endocrine …, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro discovery in 1984, evolving
via descriptive and phenomenological studies to detailed mapping of the signalling
pathways, gene- and protein expression patterns, molecular and biochemical effector ... Cited by 21 - Related articles - BL Direct - All 6 versions
