- ►nih.gov M Maggio, JM Guralnik, DL Longo, L Ferrucci - Journals of Gerontology Series A: Biological and …, 2006 - Geron Soc America The human interleukin IL-6 was originally cloned in 1986. In 1993, William
Ershler, in his article "IL-6: A Cytokine for Gerontologists," indicated IL-6 as
one of the main signaling pathways modulating the complex relationship ... Cited by 57 - Related articles - BL Direct - All 5 versions
K ALEXANDRAKI, C PIPERI, C KALOFOUTIS, … - Annals of the New York Academy of Sciences, 2006 - ingentaconnect.com Population-based studies have shown strong relationship between inflammatory
markers and metabolic disturbances, obesity, and atherosclerosis, whereas
inflammation has been considered as a “common soil” between these ... Cited by 50 - Related articles - BL Direct - All 4 versions
N Rasouli, PA Kern - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Context: Adipose tissue is increasingly recognized as an active endocrine organ
with many secretory products and part of the innate immune system. With obesity,
macrophages infiltrate adipose tissue, and numerous adipocytokines are ... Cited by 39 - Related articles - All 3 versions
C Handschin, BM Spiegelman - Nature, 2008 - pubmedcentral.nih.gov The reduction in physical activity, resulting from shifts in the nature of work
and the replacement of muscle with machine in the developed world, has driven a
dramatic increase in the incidence of many chronic diseases. In addition to ... Cited by 38 - Related articles - All 8 versions
- ►nih.gov C Handschin, CS Choi, S Chin, S Kim, D … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig 1 Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical
School, Boston, Massachusetts, USA. 2 Institute of Physiology and Zurich Center
for Integrative Human Physiology, University of Zurich, Zurich, ... Cited by 37 - Related articles - BL Direct - All 9 versions
- ►physiology.org BK Pedersen, MA Febbraio - Physiological reviews, 2008 - Am Physiological Soc Skeletal muscle has recently been identified as an endocrine organ. It has,
therefore, been suggested that cytokines and other peptides that are produced,
expressed, and released by muscle fibers and exert paracrine, autocrine, or ... Cited by 29 - Related articles - All 4 versions
- ►diabetesjournals.org NB Ruderman, C Keller, AM Richard, AK Saha, … - Diabetes, 2006 - Am Diabetes Assoc Interleukin (IL)-6 is a pleiotropic hormone that has both proinflammatory and
anti-inflammatory actions. AMP-activated protein kinase (AMPK) is a fuel-sensing
enzyme that among its other actions responds to decreases in cellular ... Cited by 27 - Related articles - BL Direct - All 5 versions
- ►nih.gov MA Febbraio - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig Obesity and its related cluster of pathophysiologic conditions including insulin
resistance, glucose intolerance, dyslipidemia, and hypertension are recognized
as growing threats to world health. It is now estimated that 10% of the ... Cited by 25 - Related articles - BL Direct - All 7 versions
SG Wannamethee, G Lowe, A Rumley, L … - Diabetes Care, 2007 - Am Diabetes Assoc RESULTS—Elevated IL-6, leptin, and low adiponectin were associated with
increased risk of type 2 diabetes even after adjustment for BMI, lifestyle
factors, preexisting cardiovascular disease, and systolic blood pressure. ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N … - Endocrine Reviews, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro
discovery in 1984, evolving via descriptive and phenomenological studies to
detailed mapping of the signalling pathways, gene- and protein expression ... Cited by 20 - Related articles - BL Direct - All 6 versions
