- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 196 - Related articles - BL Direct - All 7 versions
M Prentki, CJ Nolan - 临床研究杂志, 2006 - journal.shouxi.net The major focus of this Review is on the mechanisms of islet ? cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of ? cell compensation for insulin resistance, ... Cited by 30 - Related articles - Cached - All 2 versions
K Srinivasan, P Ramarao - Indian Journal of Medical Research, 2007 - icmr.nic.in Type 2 diabetes is a complex and heterogeneous disorder presently affecting more
than 100 million people worldwide and causing serious socio-economic problems.
Appropriate experimental models are essential tools for understanding the ... Cited by 25 - Related articles - View as HTML - BL Direct - All 3 versions
- ►diabetesjournals.org M Fraenkel, M Ketzinel-Gilad, Y Ariav, O … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Unexpectedly, rapamycin worsened hyperglycemia in diabetic P. obesus
without affecting glycemia in normoglycemic controls. There was a 10-fold
increase of serum insulin in diabetic P. obesus compared with controls; ... Cited by 20 - Related articles - BL Direct - All 4 versions
A Jörns, KJ Rath, O Bock, S Lenzen - Diabetologia, 2006 - Springer Abstract Aims/hypothesis It has recently been proposed that IL-1β may be
responsible for beta cell death in type 2 diabetes mellitus. Major support for
this assumption was derived from experiments in the gerbil Psammomys obesus ... Cited by 10 - Related articles - All 4 versions
H Einat, N Kronfeld-Schor, D Eilam - Behavioural brain research, 2006 - Elsevier The present study examined the effect of simulated change in day length on the
behavior of a diurnal rodent, the fat sand rat (a species of gerbil). Animals
were housed under a short photoperiod (5/19 light/dark cycle) for 3 weeks ... Cited by 10 - Related articles - All 5 versions
- ►diabetesjournals.org S Weksler-Zangen, I Raz, S Lenzen, A Jörns, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Hyperglycemic Cohen diabetes–sensitive rats exhibited reduced
pancreatic weight with lipid deposits and interleukin-1β–positive macrophage
infiltration in the exocrine pancreas. Islet morphology was preserved, and ... Cited by 9 - Related articles - BL Direct - All 3 versions
V Attali, M Parnes, Y Ariav, E Cerasi, N Kaiser … - Endocrinology, 2006 - Endocrine Soc Succinate stimulates insulin secretion and proinsulin biosynthesis. We studied
the effects of reduced nicotinamide adenine dinucleotide phosphate
(NADPH)-modulating pathways on glucose- and succinate-stimulated insulin ... Cited by 5 - Related articles - BL Direct - All 4 versions
E Bachar, Y Ariav, M Ketzinel-Gilad, E Cerasi, … - PLoS One, 2009 - pubmedcentral.nih.gov We found that glucose amplifies palmitate-induced ER stress by increasing IRE1α
protein levels and activating the JNK pathway, leading to increased β-cell
apoptosis. Moreover, glucose increased mTORC1 activity and its inhibition ... Cited by 5 - Related articles - All 5 versions
