JS Skyler - Clinical Pharmacology & Therapeutics, 2007 - nature.com Type 1 diabetes mellitus (T1D) arises from selective immunologically mediated destruction of
the insulin-producing -cells in the pancreatic islets of Langerhans with consequent insulin
deficiency. 1, 2 This occurs in genetically susceptible individuals and is a ... Cited by 33 - Related articles - All 4 versions
H Peng, W Hagopian - Reviews in Endocrine & Metabolic Disorders, 2006 - Springer Abstract Environmental factors appear to play an important role in the pathogenesis of
childhood-onset type 1 diabetes (T1D). The most important factors are thought to be
infectious, dietary, perinatal, and psychosocial. Enterovi- ruses (especially Coxsackie B ... Cited by 23 - Related articles - BL Direct - All 3 versions
B Faideau, E Larger, F Lepault, JC Carel, C Boitard - Diabetes, 2005 - Am Diabetes Assoc Whether autoimmunity results primarily from a defect of the immune system, target organ
dysfunction, or both remains an open issue in most human autoimmune diseases. The highly
multigenic background on which diabetes develops in the NOD mouse and in the human ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►pubget.com [PDF] P Achenbach, K Warncke, J Reiter, AJK Williams, AG … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Combinations of autoantibody character- istics, including antibody
number, titre, subclass and epitope have been shown to stratify type 1 diabetes risk in islet
autoantibody-positive relatives. The aim of this study was to determine whether ... Cited by 15 - Related articles - BL Direct - All 6 versions
LC Stene, E Witsø, PA Torjesen, T Rasmussen, P … - Journal of Autoimmunity, 2007 - Elsevier We describe the design of the MIDIA study and present serial islet autoantibody data from 3 months
of age in the 526 first enrolled children from the general population carrying the type 1 diabetes
high-risk HLA-DRB1*0401-DQA1*03-DQB1*0302/DRB1*0301-DQA1*05-DQB1*02 ... Cited by 10 - Related articles - All 4 versions
P Achenbach, M Schlosser, AJK Williams, L Yu, PW … - Clinical Immunology, 2007 - Elsevier The aim of the workshop was to assess whether four laboratories could reproducibly measure
insulin autoantibody (IAA) affinity in coded sera from non-diabetic relatives of patients with type
1 diabetes, newly diagnosed patients, and healthy blood donors, and whether combining ... Cited by 8 - Related articles - All 3 versions
A Mayr, M Schlosser, N Grober, H Kenk, AG Ziegler, E … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—At first GADA appearance, affinity ranged from 10 7 to 10 10 l/mol. Affinity was higher
in multiple islet autoantibody-positive children (P < 0.0001) and in HLA DR3–positive children
(P = 0.006). GADA affinities were >10 9 l/mol in 52 of 53 multiple autoantibody-positive ... Cited by 8 - Related articles - BL Direct - All 5 versions
- ►rupress.org M Oresic, S Simell, M Sysi-Aho, K Nanto- … - Journal of Experimental …, 2008 - jem.rupress.org The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating
progress toward β cell failure, and factors determining time of presentation of clinical diabetes
are poorly understood. We investigated changes in the serum metabolome prospectively ... Cited by 11 - Related articles - All 6 versions
A Willcox, SJ Richardson, AJ Bone, AK Foulis, … - Clin Exp …, 2009 - interscience.wiley.com The immunopathology of type 1 diabetes (T1D) has proved difficult to study in man because
of the limited availability of appropriate samples, but we now report a detailed study charting
the evolution of insulitis in human T1D. Pancreas samples removed post-mortem from 29 ... Cited by 6 - Related articles - All 3 versions
- ►jimmunol.org C Tian, MJI Ansari, J Paez-Cortez, J Bagley, … - The Journal of …, 2007 - Am Assoc Immnol We have previously shown that the development of type 1 diabetes (T1D) can be prevented in
nonobese diabetic (NOD) mice by reconstitution with autologous hemopoietic stem cells retrovirally
transduced with viruses encoding MHC class II IA β-chain molecules associated with ... Cited by 5 - Related articles - All 5 versions
