JS Skyler - Clinical Pharmacology & Therapeutics, 2007 - nature.com Type 1 diabetes mellitus (T1D) arises from selective immunologically mediated destruction of
the insulin-producing -cells in the pancreatic islets of Langerhans with consequent insulin
deficiency. 1, 2 This occurs in genetically susceptible individuals and is a ... Cited by 33 - Related articles - All 4 versions
EB Tsai, NA Sherry, JP Palmer, KC Herold - Diabetologia, 2006 - Springer Abstract An understanding of the natural history of beta cell responses is an essential prerequisite
for interventional studies designed to prevent or treat type 1 diabetes. Here we review published
data on changes in insulin responses in humans with type 1 diabetes. We also describe a ... Cited by 33 - Related articles - BL Direct - All 3 versions
EAM Gale - Diabetologia, 2007 - Springer Biological science notoriously leads us into a world of increasing complexity, and concepts that
purport to re- arrange familiar observations into a new and simpler pattern therefore merit careful
consideration. Such is the accelerator hypothesis, proposed by Terry Wilkin [1]. In this ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Pietropaolo, E Barinas-Mitchell, LH Kuller - Diabetes, 2007 - Am Diabetes Assoc Diabetes is an emblematic example of a heterogeneous disease. Systemic inflammation has
emerged as a prominent factor in the type 2 diabetes pathoetiology, but it remains ill-defined
in type 1 diabetes. There is a wide spectrum of associations between inflammatory ... Cited by 11 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org E Akirav, JA Kushner, KC Herold - Diabetes, 2008 - Am Diabetes Assoc RESULTS— The loss of β-cells that characterizes type 1 diabetes reflects the net effects of destruction
and regeneration. These processes have been examined in the nonobese diabetic (NOD)
mouse; uncertainty remains about β-cell dynamics in humans. Islet inflammation ... Cited by 10 - Related articles - All 4 versions
AV Matveyenko, PC Butler - Diabetes Obes Metab, 2008 - interscience.wiley.com Regulation of blood glucose concentrations requires an adequate number of β-cells that respond
appropriately to blood glucose levels. β-Cell mass cannot yet be measured in humans in
vivo, necessitating autopsy studies, although both pre- and postmorbid changes may ... Cited by 9 - Related articles - All 2 versions
A Willcox, SJ Richardson, AJ Bone, AK Foulis, … - Clin Exp …, 2009 - interscience.wiley.com The immunopathology of type 1 diabetes (T1D) has proved difficult to study in man because
of the limited availability of appropriate samples, but we now report a detailed study charting
the evolution of insulitis in human T1D. Pancreas samples removed post-mortem from 29 ... Cited by 6 - Related articles - All 3 versions
- ►sb-roscoff.fr [PDF] H Stukenbrock, R Mussmann, M Geese, Y … - Journal of medicinal …, 2008 - pubs.acs.org Recently, the serine/threonine kinase glycogen synthase kinase-3 (GSK-3) emerged as a regulator
of pancreatic β cell growth and survival. On the basis of the previous observation that GSK-3
inhibitors like 1-azakenpaullone promote β cell protection and replication, paullone ... Cited by 5 - Related articles - All 6 versions
E Oetjen, R Blume, I Cierny, C Schlag, A Kutschenko, R … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Inappropriate insulin secretion and biosyn- thesis are hallmarks of
beta cell dysfunction and contribute to the progression from a prediabetic state to overt diabetes
mellitus. During the prediabetic state, beta cells are exposed to elevated levels of ... Cited by 5 - Related articles - BL Direct - All 4 versions
DJ Klinke… - PLoS ONE, 2008 - pubmedcentral.nih.gov The histopathology results identifying insulin containing islets in patients younger than 20 years
of age were extracted from three different studies. The results for 105 patients were stratified
by duration of diabetic symptoms and age at onset. Linear regression and a ... Cited by 5 - Related articles - All 4 versions
