- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a
role in the pathogenesis of diabetes, contributing to pancreatic β-cell loss
and insulin resistance. Components of the unfolded protein response (UPR) ... Cited by 89 - Related articles - BL Direct - All 5 versions
- ►shouxi.net D Mozaffarian, MB Katan, A Ascherio, MJ … - The New England journal of medicine, 2006 - nejm.highwire.org Trans fats, unsaturated fatty acids with at least one double bond in the trans
configuration (Figure 1), are formed during the partial hydrogenation of
vegetable oils, a process that converts vegetable oils into semisolid fats ... Cited by 75 - Related articles - BL Direct - All 13 versions
- ►nih.gov MA Bogoyevitch, B Kobe - Microbiology and Molecular Biology Reviews, 2006 - mmbr.highwire.org The c-Jun N-terminal kinases (JNKs) are members of a larger group of
serine/threonine (Ser/Thr) protein kinases from the mitogen-activated protein
kinase family. JNKs were originally identified as stress-activated protein ... Cited by 68 - Related articles - BL Direct - All 7 versions
- ►pnas.org G Tuncman, J Hirosumi, G Solinas, L Chang, M … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and
interfere with insulin action in cultured cells and whole animals. Obesity
increases total JNK activity, and JNK1, but not JNK2, deficiency results in ... Cited by 69 - Related articles - BL Direct - All 8 versions
- ►jlr.org NM Borradaile, X Han, JD Harp, SE Gale, DS … - The Journal of Lipid Research, 2006 - ASBMB Cell dysfunction and death induced by lipid accumulation in nonadipose tissues,
or lipotoxicity, may contribute to the pathogenesis of obesity and type 2
diabetes. However, the mechanisms leading to lipotoxic cell death are ... Cited by 55 - Related articles - BL Direct - All 5 versions
GL Johnson, K Nakamura - Biochimica et biophysica acta, 2007 - pubmedcentral.nih.gov There are three JNK genes (JNK1, JNK2, JNK3). JNK1 and JNK2 are ubiquitously
expressed while JNK3 is restricted to brain, heart and testes [1, 4, 7, 8].
Differential splicing and exon usage results in multiple isoforms of the ... Cited by 51 - Related articles - All 4 versions
- ►ahajournals.org A Xu, AWK Tso, BMY Cheung, Y Wang, N Wat … - Circulation, 2007 - Am Heart Assoc Methods and Results— In the present study, 495 nondiabetic adults from the
population-based Hong Kong Cardiovascular Risk Factor Prevalence Study were
prospectively followed up for 5 years. The relationship of serum A-FABP ... Cited by 51 - Related articles - All 5 versions
H Kaneto, N Katakami, D Kawamori, T … - Antioxidants & redox signaling, 2007 - liebertonline.com F AILURE OF PANCREATIC cells is the common characteris- tic of type 1 and type 2
diabetes. Type 1 diabetes melli- tus is induced by destruction of pancreatic
cells, which is mediated by an autoimmune mechanism and the consequent ... Cited by 47 - Related articles - BL Direct - All 4 versions
G Boden - Current diabetes reports, 2006 - Springer Plasma free fatty acid (FFA) levels are elevated in obesity. FFA, by causing
insulin resistance in muscle, liver, and endothelial cells, contributes to the
development of type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, ... Cited by 41 - Related articles - BL Direct - All 4 versions
