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Scholar Results 1 - 10 of 12 citing Bottino: Multifaceted therapeutic approaches for a multigenic disease. (0.09 sec) 

Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus


K Maiese, SD Morhan, ZZ Chong - Current neurovascular research, 2007 - pubmedcentral.nih.gov
Diabetes mellitus (DM) affects approximately 170 million individuals worldwide
and is expected to alter the lives of at least 366 million individuals within a
future span of 25 years. Of even greater concern is the premise that these ...
Cited by 46 - Related articles - BL Direct - All 6 versions

Mechanistic insights into diabetes mellitus and oxidative stress


K Maiese, ZZ Chong, YC Shang - Current medicinal chemistry, 2007 - pubmedcentral.nih.gov
Diabetes mellitus (DM) is a significant healthcare concern worldwide that
affects more than 165 million individuals leading to cardiovascular disease,
nephropathy, retinopathy, and widespread disease of both the peripheral and ...
Cited by 27 - Related articles - BL Direct - All 6 versions

Long-term engraftment following transplantation of pig pancreatic primordia into non- …


SA Rogers, F Chen, MR Talcott, C Faulkner … - Xenotransplantation, 2007 - interscience.wiley.com
Background: Transplantation therapy for human diabetes is limited by a shortage
of donor organs, and transplant function diminished over time by cell death and
limited potential for expansion of beta cells in pancreas or islets. ...
Cited by 11 - Related articles - BL Direct - All 4 versions

Gene therapy for type 1 diabetes


A D'Anneo, P Rood, R Bottino, AN … - Immunologic research, 2006 - Springer
This review, in addition to updating the growing list of type 1 dia-
betes–relevant gene therapies, offers an outline of short-term objec- tives
that can readily be met to move, at least, adenoviral and adeno-associated ...
Cited by 6 - Related articles - BL Direct - All 5 versions

Glucose tolerance normalization following transplantation of pig pancreatic primordia into …


SA Rogers, F Chen, M Talcott, H Liapis, … - Transplant immunology, 2006 - Elsevier
Pancreas or pancreatic islet transplantation in humans is limited by organ
availability, and success of the latter is negatively impacted upon by tissue
loss post-transplantation and limited potential for expansion of beta ...
Cited by 7 - Related articles - All 4 versions

Normalization of glucose post-transplantation into diabetic rats of pig pancreatic primordia …


SA Rogers, MR Hammerman - Organogenesis, 2008 - pubmedcentral.nih.gov
Theoretically, if employed for clinical use in humans, pancreatic primordia
could be harvested immediately prior to implantation. However, practically it
would be best if pancreatic primordia could be stored in vitro for a period ...
Cited by 1 - Related articles - All 6 versions

Organogenesis of Kidney and Endocrine Pancreas: The Window Opens


MR Hammerman - Organogenesis, 2007 - pubmedcentral.nih.gov
Growing new organs in situ by implanting developing animal organ primordia
(organogenesis) represents a novel solution to the problem of limited supply for
human donor organs that offers advantages relative to transplanting ...
Related articles - BL Direct - All 5 versions

The Dual Peroxisome Proliferator-Activated Receptor {alpha}/{gamma} Activator Muraglitazar …

- aspetjournals.org
E Tozzo, R Ponticiello, JA Swartz, D Farrelly … - Journal of Pharmacology and Experimental …, 2007 - ASPET
There are two major defects in type 2 diabetes: 1) insulin resistance and 2)
insulin deficiency due to loss of -cell function. Here we demonstrated that
treatment with muraglitazar (a dual peroxisome proliferator-activated ...
Related articles - All 4 versions

Tissue Engineering Applications in Endocrinology


MR Hammerman - growth - Springer
65.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . 939 65.2
Type 1 and Type 2 Diabetes Mellitus . . . . . 940 65.2.1 Treatment Modalities
for Diabetes—Limitations of Pancreas or Islet Transplantation . . . . . . ...
Related articles

[PDF] ROUNDS


N RAZACK, D WHERRETT, L LEITER, G … - genetics - endocrinologyrounds.ca
Significant advances in understanding the pathogenesis of type 1 diabetes
mellitus (T1DM) have led to a multitude of opportunities for intervention.
Specifically, a more thor- ough understanding has evolved of the potential ...
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