- ►diabetesjournals.org TA Buchanan, A Xiang, SL Kjos, R Watanabe - Diabetes Care, 2007 - Am Diabetes Assoc Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset or first recognition
during pregnancy. As such, GDM is the product of routine glucose tolerance screening that is
currently carried out in otherwise healthy individuals. Like other forms of hyperglycemia, ... Cited by 170 - Related articles - BL Direct - All 17 versions
- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►nih.gov R Eldor, A Yeffet, K Baum, V Doviner, D … - Proceedings of the …, 2006 - National Acad Sciences Type 1 diabetes is characterized by the infiltration of inflammatory cells into pancreatic islets
of Langerhans, followed by the selective and progressive destruction of insulin-secreting beta
cells. Islet-infiltrating leukocytes secrete cytokines such as IL-1β and IFN-γ, which ... Cited by 51 - Related articles - BL Direct - All 8 versions
P Marchetti, M Bugliani, R Lupi, L Marselli, M Masini, U … - Diabetologia, 2007 - Springer Page 1. ARTICLE The endoplasmic reticulum in pancreatic beta cells of type 2
diabetes patients P. Marchetti & M. Bugliani & R. Lupi & L. Marselli & M. Masini &
U. Boggi & F. Filipponi & GC Weir & DL Eizirik & M. Cnop Received ... Cited by 47 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org N Welsh, M Cnop, I Kharroubi, M Bugliani, R Lupi, P … - Diabetes, 2005 - Am Diabetes Assoc Different degrees of β-cell failure and apoptosis are present in type 1 and type 2 diabetes. It has
been recently suggested that high glucose–induced β-cell apoptosis in type 2 diabetes shares
a final common pathway with type 1 diabetes, involving interleukin-1β (IL-1β) production ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org N Herbach, B Rathkolb, E Kemter, L Pichl, M Klaften, … - Diabetes, 2007 - Am Diabetes Assoc The novel diabetic mouse model Munich Ins2 C95S was discovered within the Munich
N-ethyl-N-nitrosourea mouse mutagenesis screen. These mice exhibit a T→A transversion in
the insulin 2 (Ins2) gene at nucleotide position 1903 in exon 3, which leads to the amino ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►endojournals.org F Ortis, AK Cardozo, D Crispim, J Storling, T … - Molecular …, 2006 - Endocrine Soc Cytokines, such as IL-1ß and TNF- , contribute to pancreatic ß-cell death in type 1 diabetes
mellitus. The transcription factor nuclear factor- B (NF- B) mediates cytokine-induced ß-cell
apoptosis. Paradoxically, NF- B has mostly antiapoptotic effects in other cell types. The ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►ulb.ac.be [PDF] P Pirot, N Naamane, F Libert, NE Magnusson, TF … - Diabetologia, 2007 - Springer Page 1. ARTICLE Global profiling of genes modified by endoplasmic reticulum stress in
pancreatic beta cells reveals the early degradation of insulin mRNAs P. Pirot & N. Naamane
& F. Libert & NE Magnusson & TF Ørntoft & AK Cardozo & DL Eizirik ... Cited by 26 - Related articles - BL Direct - All 6 versions
R Eldor, I Raz - Diabetes Research and Clinical Practice, 2006 - Elsevier Type 2 diabetes (T2D) is thought to be a culmination of two seemingly distinct processes, insulin
resistance and beta cell failure, both of which have been closely linked to obesity. Here, we focus
on the various deleterious effects of obesity on the beta cell. Obesity can affect beta cells ... Cited by 25 - Related articles - All 9 versions
