T Yamauchi, Y Nio, T Maki, M Kobayashi, T … - Nature - xn-- … Page 1. 332 VOLUME 13 | NUMBER 3 | MARCH 2007 NATURE MEDICINE Targeted
disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and
metabolic actions Toshimasa Yamauchi 1–3,7 ,Yasunori ... Cited by 170 - Related articles - View as HTML - BL Direct - All 10 versions
T Kadowaki, T Yamauchi, N Kubota - FEBS letters, 2008 - Elsevier Adiponectin is an abundantly expressed adipokine in adipose tissue and has direct insulin sensitizing
activity. A decrease in the circulating levels of adiponectin by interactions between genetic factors
and environmental factors causing obesity has been shown to contribute to the ... Cited by 43 - Related articles - All 10 versions
AT Hattersley, ER Pearson - Endocrinology, 2006 - Endocrine Soc Defining the molecular genetics of diabetes gives new insight into the underlying etiology and
so should help improve treatment. The genetic etiology is now known for most patients with
ß-cell monogenic diabetes, allowing genetic classification. We review how this genetic ... Cited by 43 - Related articles - BL Direct - All 8 versions
A Szollosi, M Nenquin, L Aguilar-Bryan, J Bryan, JC … - Journal of Biological …, 2007 - ASBMB In adult β-cells glucose-induced insulin secretion involves two mechanisms (a) a K ATP
channel-dependent Ca 2+ influx and rise of cytosolic [Ca 2+ ] c and (b) a K ATP channel-independent
amplification of secretion without further increase of [Ca 2+ ] c . Mice lacking the high ... Cited by 20 - Related articles - All 5 versions
SFA Grant, H Hakonarson - Expert Rev. Mol. Diagn., 2007 - mp.medscape.com Genetic diversity, most notably through single nucleotide polymorphisms and copy-number
variation, together with specific environmental exposures, contributes to both disease susceptibility
and drug response variability. It has proved difficult to isolate disease genes that confer ... Cited by 17 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org JC Henquin, D Dufrane, M Nenquin - Diabetes, 2006 - Am Diabetes Assoc Pancreatic islets were isolated from 16 nondiabetic organ donors and, after culture for ∼2 days
in 5 mmol/l glucose, were perifused to characterize nutrient-induced insulin secretion in human
islets. Stepwise increases from 0 to 30 mmol/l glucose (eight 30-min steps) evoked ... Cited by 16 - Related articles - BL Direct - All 5 versions
L Agius - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier Type-2 diabetes is associated with impaired glucose clearance by the liver in the postprandial
state, and with elevated glucose production in the post-absorptive state. New targets within the
liver are currently being investigated for development of antihyperglycaemic drugs for ... Cited by 17 - Related articles - All 17 versions
- ►diabetesjournals.org D Johnson, RM Shepherd, D Gill, T Gorman, DM Smith, … - Diabetes, 2007 - Am Diabetes Assoc Because glucokinase is a metabolic sensor involved in the regulated release of insulin, we have
investigated the acute actions of novel glucokinase activator compound 50 (GKA50) on islet
function. Insulin secretion was determined by enzyme-linked immunosorbent assay, and ... Cited by 15 - Related articles - BL Direct - All 6 versions
- ►ucsc.edu [PDF] YB Kim, SS Kalinowski, J Marcinkeviciene - Biochemistry, 2007 - pubs.acs.org Cooperativity with glucose is a key feature of human glucokinase (GK), allowing its crucial role
as a glucose sensor in hepatic and pancreatic cells. We studied the changes in enzyme intrinsic
tryptophan fluorescence induced by binding of different ligands to this monomeric ... Cited by 14 - Related articles - All 4 versions
- ►jbc.org A Szollosi, M Nenquin, JC Henquin - Journal of Biological Chemistry, 2007 - ASBMB A current model ascribes glucose-induced insulin secretion to the interaction of a triggering pathway
(K ATP channel-dependent Ca 2+ influx and rise in cytosolic [Ca 2+ ] c ) and an amplifying pathway
(K ATP channel-independent augmentation of secretion without further increase of [Ca 2+ ... Cited by 14 - Related articles - All 6 versions
