- ►daegu.ac.kr [PDF] R Sladek, G Rocheleau, J Rung, C Dina, L … - Nature, 2007 - nature.com Type 2 diabetes mellitus results from the interaction of environmental factors
with a combination of genetic variants, most of which were hitherto unknown. A
systematic search for these variants was recently made possible by the ... Cited by 778 - Related articles - BL Direct - All 14 versions
R Saxena, L Gianniny, NP Burtt, V Lyssenko, … - Diabetes, 2006 - Am Diabetes Assoc Recently, common noncoding variants in the TCF7L2 gene were strongly associated
with increased risk of type 2 diabetes in samples from Iceland, Denmark, and the
US We genotyped 13 single nucleotide polymorphisms (SNPs) across TCF7L2 in ... Cited by 160 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] N Grarup, CS Rose, EA Andersson, G Andersen … - Diabetes, 2007 - Am Diabetes Assoc Page 1. Studies of Association of Variants Near the HHEX, CDKN2A/B, and IGF2BP2
Genes With Type 2 Diabetes and Impaired Insulin Release ... Cited by 60 - Related articles - BL Direct - All 3 versions
- ►nih.gov MI McCarthy, E Zeggini - Current Diabetes Reports, 2006 - Springer Introduction The growing prevalence of type 2 diabetes and obesity in societies
worldwide is widely recognized as among the greatest threats to global health in
the coming century [1]. Nevertheless, we remain far from a comprehensive ... Cited by 31 - Related articles - BL Direct - All 8 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human
population. Like humans, mice have a wide range of diabetes-related phenotypes.
The inbred mouse strains differ in the response of their critical ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►jbc.org H Im, M Manolopoulou, E Malito, Y Shen, J … - Journal of Biological Chemistry, 2007 - ASBMB Insulin-degrading enzyme (IDE) is a zinc metalloprotease that hydrolyzes
amyloid- (A ) and insulin, which are peptides associated with Alzheimer disease
(AD) and diabetes, respectively. Our previous structural analysis of ... Cited by 21 - Related articles - All 5 versions
E Zeggini - Diabetic Medicine, 2007 - pubmedcentral.nih.gov The field of complex disease genetics has witnessed rapid progress over the past
few months. The advent of genome-wide association scans (GWAS) has mediated a
change in gear and the Type 2 diabetes (T2D) research community has set an ... Cited by 15 - Related articles - BL Direct - All 6 versions
- ►endojournals.org [PDF] Y Furukawa, T Shimada, H Furuta, S Matsuno, … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Page 1. Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly
associated with type 2 diabetes in a Japanese population ... Cited by 15 - Related articles - BL Direct - All 3 versions
MI McCarthy, E Zeggini - Trends in Pharmacological Sciences, 2007 - Elsevier Type 2 diabetes is a complex, multifactorial disease, for which genetic and
environmental factors jointly determine susceptibility. Disentangling the
genetic aetiology of Type 2 diabetes has proven a challenging task, ... Cited by 10 - Related articles - All 3 versions
- ►genetics.org SJ Macdonald, AD Long - Genetics, 2007 - Genetics Soc America We develop and implement a strategy to map QTL in two synthetic populations of
Drosophila melanogaster each initiated with eight inbred founder strains. These
recombinant populations allow simultaneous estimates of QTL location, ... Cited by 5 - Related articles - BL Direct - All 9 versions
