- ►diabetesjournals.org K Morino, KF Petersen, GI Shulman - Diabetes, 2006 - Am Diabetes Assoc Recent studies using magnetic resonance spectroscopy have shown that decreased
insulin-stimulated muscle glycogen synthesis due to a defect in insulin-stimulated glucose transport
activity is a major factor in the pathogenesis of type 2 diabetes. The molecular mechanism ... Cited by 125 - Related articles - BL Direct - All 5 versions
M Roden - Nature Reviews Endocrinology, 2006 - nature.com Hepatic steatosis is defined by an increased content of hepatocellular lipids (HCLs) and is frequently
observed in insulin-resistant states including type 2 diabetes mellitus. A dietary excess of saturated
fat contributes significantly to HCL accumulation. Elevated HCL levels mainly account for ... Cited by 73 - Related articles - BL Direct - All 4 versions
M Mogensen, K Sahlin, M Fernström, D Glintborg, BF … - Diabetes, 2007 - Am Diabetes Assoc We tested the hypothesis of a lower respiratory capacity per mitochondrion in skeletal muscle
of type 2 diabetic patients compared with obese subjects. Muscle biopsies obtained from 10
obese type 2 diabetic and 8 obese nondiabetic male subjects were used for assessment ... Cited by 50 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org J Kim, Y Wei, JR Sowers - Circulation research, 2008 - Am Heart Assoc Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the cardiometabolic
syndrome, including hypertension and dyslipidemia, that collectively contribute to a substantial
risk for cardiovascular disease. Metabolic actions of insulin in classic insulin target tissues ... Cited by 49 - Related articles - All 6 versions
M Roden - International Journal of Obesity, 2005 - nature.com REL-DM exhibit defects in mitochondrial oxidation and phosphorylation. Increased FFA availability
results in accumulation of intramyocellular fatty acyl-CoA (FA-CoA) inducing a series of
alterations: (i) inhibition of insulin signaling, (ii) reduction of insulin-(in)dependent glucose ... Cited by 42 - Related articles - BL Direct - All 5 versions
J Szendroedi, AI Schmid, M Chmelik, C Toth, A … - PLoS …, 2007 - medicine.plosjournals.org We measured G-6-P, ATP synthetic flux (ie, synthesis) and lipid contents of skeletal muscle with
31 P/ 1 H magnetic resonance spectroscopy in ten patients with T2DM and in two control
groups: ten sex-, age-, and body mass-matched elderly people; and 11 younger healthy ... Cited by 40 - Related articles - Cached - All 9 versions
C Boesch, J Machann, P Vermathen, F … - NMR in …, 2006 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 30 - Related articles - BL Direct - All 2 versions
CS Stump, EJ Henriksen, Y Wei, JR Sowers - Annals of Medicine, 2006 - informahealthcare.com Skeletal muscle constitutes the largest insulin‐sensitive tissue in the body and is the primary
site for insulin‐stimulated glucose utilization. Skeletal muscle resistance to insulin is fundamental
to the metabolic dysregulation associated with obesity and physical inactivity, and ... Cited by 31 - Related articles - BL Direct - All 8 versions
- ►physiology.org MC Levin, M Monetti, MJ Watt, MP Sajan, … - American Journal of …, 2007 - Am Physiological Soc Insulin resistance and type 2 diabetes are frequently accompanied by lipid accumulation in skeletal
muscle. However, it is unknown whether primary lipid deposition in skeletal muscle is sufficient
to cause insulin resistance or whether the type of muscle fiber, oxidative or glycolytic fiber, ... Cited by 16 - Related articles - BL Direct - All 4 versions
SM Hirabara, LR Silveira, F Abdulkader, … - Journal of cellular …, 2007 - interscience.wiley.com Increased plasma levels of free fatty acids (FFA) occur in states of insulin resistance such as
type 2 diabetes mellitus, obesity, and metabolic syndrome. These high levels of plasma FFA
seem to play an important role for the development of insulin resistance but the ... Cited by 16 - Related articles - BL Direct - All 5 versions
