- ►meduni-graz.at [PDF] G Haemmerle, A Lass, R Zimmermann, G Gorkiewicz, … - Science, 2006 - sciencemag.org Fat tissue is the most important energy depot in vertebrates. The release of free fatty acids
(FFAs) from stored fat requires the enzymatic activity of lipases. We showed that genetic inactivation
of adipose triglyceride lipase (ATGL) in mice increases adipose mass and leads to ... Cited by 170 - Related articles - BL Direct - All 11 versions
- ►cell.com A Lass, R Zimmermann, G Haemmerle, M Riederer, G … - Cell Metabolism, 2006 - Elsevier Adipose triglyceride lipase (ATGL) was recently identified as an important triacylglycerol
(TG) hydrolase promoting the catabolism of stored fat in adipose and nonadipose tissues. We
now demonstrate that efficient ATGL enzyme activity requires activation by CGI-58. ... Cited by 121 - Related articles - All 13 versions
- ►jbc.org M Schweiger, R Schreiber, G Haemmerle, A Lass, … - Journal of Biological …, 2006 - ASBMB The mobilization of free fatty acids from adipose triacylglycerol (TG) stores requires the activities
of triacylglycerol lipases. In this study, we demonstrate that adipose triglyceride lipase
(ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to TG ... Cited by 89 - Related articles - All 6 versions
- ►jlr.org DL Brasaemle - The Journal of Lipid Research, 2007 - ASBMB The majority of eukaryotic cells synthesize neutral lipids and package them into cytosolic lipid
droplets. In vertebrates, triacylglycerol-rich lipid droplets of adipocytes provide a major energy
storage depot for the body, whereas cholesteryl ester-rich droplets of many other cells ... Cited by 76 - Related articles - All 5 versions
V Schoenborn, IM Heid, C Vollmert, A Lingenhel, TD … - Diabetes, 2006 - Am Diabetes Assoc Adipose triglyceride lipase (ATGL) was recently described to predominantly perform the initial
step in triglyceride hydrolysis and therefore seems to play a pivotal role in the lipolytic catabolism
of stored fat in adipose tissue. In the first study investigating genetic variations within the ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►physiology.org M Ryden, J Jocken, V van Harmelen, A … - American Journal of …, 2007 - Am Physiological Soc Hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) regulate adipocyte lipolysis
in rodents. The purpose of this study was to compare the roles of these lipases for lipolysis in
human adipocytes. Subcutaneous adipose tissue was investigated. HSL and ATGL ... Cited by 32 - Related articles - BL Direct - All 5 versions
WT Festuccia, M Laplante, M Berthiaume, Y Gelinas, Y … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis The aim of this study was to investigate the effect and mechanisms
of action of in vivo peroxisome proliferator-activated receptor γ (PPARγ) activation on white adipose
tissue (WAT) lipolysis and NEFA metabolism. Materials and methods Study rats were ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►physiology.org K Jaworski, E Sarkadi-Nagy, RE Duncan, … - American Journal of …, 2007 - Am Physiological Soc Triacylglycerol (TAG) stored in adipose tissue can be rapidly mobilized by the hydrolytic action
of lipases, with the release of fatty acids (FA) that are used by other tissues during times of energy
deprivation. Unlike synthesis of TAG, which occurs not only in adipose tissue but also in ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►cell.com D Langin, P Arner - Trends in Endocrinology & Metabolism, 2006 - Elsevier Catecholamines and natriuretic peptides stimulate human adipocyte lipolysis through an increase
in cAMP and cGMP levels, resulting in phosphorylation and activation of hormone-sensitive
lipase. A defect in hormone-sensitive lipase expression might contribute to the resistance ... Cited by 30 - Related articles - All 7 versions
- ►endojournals.org JWE Jocken, D Langin, E Smit, WHM Saris, C … - Journal of Clinical …, 2007 - Endocrine Soc Results: Fasting insulin levels and the degree of insulin resistance (using the homeostasis model
assessment index for insulin resistance) were negatively correlated with ATGL and HSL protein
expression, independent of age, gender, fat cell size, and body composition. Both mRNA ... Cited by 28 - Related articles - BL Direct - All 8 versions
