P Pandiyan, L Zheng, S Ishihara, J Reed, MJ … - Nature - 128.252.17.197 A key issue in mammalian immunology is how CD4+CD25+Foxp3+ regulatory T cells
(Treg cells) suppress immune responses. Here we show that Treg cells induced
apoptosis of effector CD4+ T cells in vitro and in vivo in a mouse model of ... Cited by 124 - Related articles - View as HTML - BL Direct - All 19 versions
RPM Sutmuller, ME Morgan, MG Netea, O … - Trends in immunology, 2006 - Elsevier Regulatory T (Treg) cells maintain peripheral tolerance and limit effector
responses to prevent excessive immune-mediated tissue damage. However, recent
research reveals that Treg cells also dampen the induction of immune ... Cited by 71 - Related articles - All 6 versions
- ►oxfordjournals.org J Yates, F Rovis, P Mitchell, B Afzali, JYS … - International immunology, 2007 - Jpn Soc Immunol CD4 + CD25 + regulatory T cells (Tregs) have far-reaching immunotherapeutic
applications, the realization of which will require a greater understanding of
the factors influencing their function and phenotype during ex vivo ... Cited by 32 - Related articles - BL Direct - All 7 versions
X Valencia, PE Lipsky - Nature Clinical Practice Rheumatology, 2007 - nature.com Dr Xavier Valencia, a physician scientist at the National Institute of Arthritis
and Musculoskeletal and Skin Diseases, NIH, identified cadherin-11 as the
synovial cadherin responsible for maintaining the synovium architecture ... Cited by 27 - Related articles - BL Direct - All 3 versions
- ►cytometry.cn [PDF] SJ Piersma, MJP Welters, SH van der Burg - Human Immunology, 2008 - Elsevier A large body of evidence indicates that the presence of regulatory T cells
(Tregs) in tumors is associated with a dampened tumor-specific immune response
and a clear negative impact on survival. Many different subsets of Tregs ... Cited by 12 - Related articles - All 5 versions
- ►nih.gov SA Long, JH Buckner - Journal of autoimmunity, 2008 - Elsevier The immune system protects itself from autoreactivity by maintaining a balance
between effector and Treg responses. Peripheral induction of Treg is one
mechanism by which this balance may be maintained. Thus, it is important to ... Cited by 13 - Related articles - All 3 versions
R Sutmuller, A Garritsen, GJ Adema - British Medical Journal, 2007 - ard.bmj.com Regulatory T cells (Treg) play a crucial role in maintaining control of
leucocytes. Several studies have shown that in vivo Treg depletion results in
autoimmune syndromes like thyroiditis, gastritis, diabetes mellitus and ... Cited by 11 - Related articles - BL Direct - All 6 versions
L Pasquali, Y Fan, M Trucco, S Ringquist - Trends in Biotechnology, 2006 - Elsevier Type 1 Diabetes (T1D) is an autoimmune disease resulting from the destruction of
pancreatic insulin-producing β cells that most frequently occurs in genetically
predisposed children. Recent observations illustrating the regenerative ... Cited by 10 - Related articles - All 5 versions
- ►nih.gov B Phillips, K Nylander, J Harnaha, J Machen, … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Microspheres carrying antisense oligonucleotides
to CD40, CD80, and CD86 were delivered into NOD mice. Glycemia was monitored to
determine disease prevention and reversal. In recipients that remained ... Cited by 9 - Related articles - All 11 versions
- ►jleukbio.org TY Wuest, J Willette-Brown, SK Durum, AA … - Journal of Leukocyte Biology, 2008 - Soc Leukocyte Biology IL-2 is essential for CD4+CD25+forkhead box P3+ (FoxP3+) naturally occurring
regulatory T cell (Treg) homeostasis and activation. Binding of IL-2 to its
receptor leads to phosphorylation of STAT5, and binding of phosphorylated ... Cited by 11 - Related articles - All 6 versions
