- ►asnjournals.org S Wang, M de Caestecker, J Kopp, G Mitu, J … - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol Longstanding diabetes causes renal injury with early dropout of podocytes,
albuminuria, glomerular and tubulointerstitial fibrosis, and progressive renal
failure. The renal pathology seems to be driven, in part, by TGF- and is ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►shouxi.net S Menini, L Amadio, G Oddi, C Ricci, C Pesce, … - Diabetes, 2006 - Am Diabetes Assoc Hyperglycemia plays a central role in diabetic nephropathy, as shown by its
prevention or retardation by strict metabolic control (1,2). The injurious
effect of hyperglycemia has been attributed to various biochemical ... Cited by 44 - Related articles - BL Direct - All 6 versions
G Wolf, FN Ziyadeh - Nephron Physiol, 2007 - content.karger.com One of the earliest clinically detectable abnormalities in diabetic nephropathy
is microalbuminuria that eventually progresses to proteinuria. The degree of
proteinuria correlates with the progression of glomerulosclerosis and ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►shouxi.net Y Ohshiro, RC Ma, Y Yasuda, J Hiraoka- … - Diabetes, 2006 - Am Diabetes Assoc Diabetes induces the activation of several protein kinase C (PKC) isoforms in
the renal glomeruli. We used PKC-β −/− mice to examine the action of PKC-β
isoforms in diabetes-induced oxidative stress and renal injury at 8 and 24 ... Cited by 38 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org W Hsueh, ED Abel, JL Breslow, N Maeda, RC … - Circulation research, 2007 - Am Heart Assoc From the Division of Endocrinology, Diabetes, and Hypertension (WH), and
Department of Medicine, Division of Cardiology (RCD), The David Geffen School of
Medicine, University of California, Los Angeles; Division of Endocrinology, ... Cited by 37 - Related articles - All 6 versions
- ►asnjournals.org CL Lin, JY Wang, YT Huang, YH Kuo, K … - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol Glomerulosclerosis and diabetic nephropathy are attributable to high glucose
induction of mesangial cell apoptosis. Whereas Wnt signaling has been found to
regulate renal morphogenesis and pathogenesis, the biologic role of Wnt/ - ... Cited by 35 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org C Szabó, A Biser, R Benkő, E Böttinger, K … - Diabetes, 2006 - Am Diabetes Assoc The activation of the poly(ADP-ribose) polymerase (PARP) plays an important role
in the pathophysiology of various diseases associated with oxidative stress. We
found increased amounts of poly(ADP) ribosylated proteins in diabetic ... Cited by 35 - Related articles - BL Direct - All 6 versions
- ►amjpathol.org DW Wong, GY Oudit, H Reich, Z Kassiri, J … - American Journal of Pathology, 2007 - ASIP Activation of the renin-angiotensin system (RAS) and the generation of
angiotensin (Ang) II play an important role in the pathogenesis of diabetic
nephropathy and blockade of the RAS in both experimental and clinical ... Cited by 34 - Related articles - BL Direct - All 8 versions
K Sharma, S RamachandraRao, G Qiu, HK Usui … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov 1 Translational Research in Kidney Disease, Division of Nephrology, Department
of Medicine, University of California, San Diego, La Jolla, California, USA. 2
Veterans Administration San Diego Healthcare System, La Jolla, California, ... Cited by 38 - Related articles - BL Direct - All 8 versions
- ►asnjournals.org SV Shah, R Baliga, M Rajapurkar, VA … - Journal of the American Society of Nephrology, 2007 - Am Soc Nephrol Chronic kidney disease is a worldwide public health problem that affects
approximately 10% of the US adult population and is associated with a high
prevalence of cardiovascular disease and high economic cost. Chronic renal ... Cited by 30 - Related articles - BL Direct - All 5 versions
