- ►jimmunol.org P Monti, M Scirpoli, A Rigamonti, A Mayr, A … - The Journal of …, 2007 - Am Assoc Immnol Identifying cell autoantigen-reactive T cells that are involved in the pathogenesis of type 1 diabetes
has been troublesome for many laboratories. Disease-relevant autoreactive T cells should be
in vivo Ag experienced. The aim of this study was to test this hypothesis and then use this ... Cited by 17 - Related articles - All 4 versions
N Zaidi, T Burster, V Sommandas, T Herrmann, BO … - … and Biophysical Research …, 2007 - Elsevier Selective inhibition of enzymes involved in antigen processing such as cathepsin E and cathepsin
D is a valuable tool for investigating the roles of these enzymes in the processing pathway.
However, the aspartic protease inhibitors, including the highly potent pepstatin A (PepA), ... Cited by 10 - Related articles - All 5 versions
L Kahmann, P Uciechowski, S Warmuth, M Malavolta, … - Biogerontology, 2006 - Springer Abstract Mild zinc deficiency is a common condition in healthy elderly individuals leading to impaired
cell-mediated immune response. Here we report the effect of improved zinc status on TH1/TH2
balance and on the activation status of T helper cells in 19 healthy elderly subjects aged ... Cited by 6 - Related articles - All 5 versions
B Wilde, S Dolff, X Cai, C Specker, J Becker, M … - Nephrology Dialysis …, 2009 - ERA-EDTA Methods. Thirty patients with WG and 18 healthy controls (HC) were included in this study. The
disease activity and extension were measured by the Birmingham Vasculitis Activity Score
(BVAS) and the Disease Extent Index (DEI). Lymphocytes from peripheral blood were ... Cited by 8 - Related articles - All 4 versions
H Tsui, S Winer, Y Chan, D Truong, L Tang, J Yantha, … - System, 1927 - interscience.wiley.com Type 1 diabetes (T1D) is caused by autoimmune β cell destruction. The early events triggering
T1D and the forces that keep diabetic autoimmunity pancreas specific have been unclear. Our
discovery that autoimmune islet destruction is not β-cell-exclusive but includes cytotoxic T ... Cited by 4 - Related articles - All 4 versions
- ►adisonline.com [PDF] M von Herrath, D Rottembourg, D Bresson - BioDrugs, 2006 - ingentaconnect.com Page 1. Biodrugs 2006; 20 (6): 341-350 N OVEL T HERAPEUTIC S TRATEGIES
1173-8804/06/0006-0341/$39.95/0 2006 Adis Data Information BV. All rights reserved. Progress
in the Development of Immune-Based Therapies for Type 1 Diabetes Mellitus ... Cited by 2 - Related articles - BL Direct - All 4 versions
T Burster, M Reich, N Zaidi, W Voelter, BO Boehm, … - … and Biophysical Research …, 2008 - Elsevier Processing of antigens by proteases in the endocytic compartments of antigen presenting cells
(APC) is essential to make them suitable for presentation as antigenic peptides to T
lymphocytes. Several proteases of the cysteine, aspartyl and serine classes are involved ... Cited by 2 - Related articles - All 3 versions
- ►nih.gov E Laughlin, G Burke, A Pugliese, B Falk, G Nepom - Clinical Immunology, 2008 - Elsevier CD4+ T cells specific for the diabetes-associated autoantigen GAD65 were analyzed using peripheral
blood samples after pancreas transplantation in subjects with T1D with clinical evidence of recurrent
autoimmune diabetes. MHC class II tetramers facilitated the identification and cloning of ... Cited by 2 - Related articles - All 4 versions
P Monti, AK Heninger, E Bonifacio - Current Diabetes Reports, 2009 - Springer Autoreactive T cells play a major role in the patho- genesis of type 1 diabetes mellitus
(T1DM) and are considered a major target of immunomodulatory strategies aimed at preventing
or delaying the disease onset. However, the T-cell response against insulin- producing β ... Cited by 1 - Related articles - All 2 versions
T Shindo, T Ishikawa, A Fukunaga, T Hori, T … - Biology of Blood and …, 2008 - Elsevier OX40 (CD134), an activation-induced costimulatory molecule, is mainly expressed on CD4 +
T cells. Several reports, including previous reports from our laboratory, suggest that OX40-mediated
signaling plays an important role in the development of graft-versus-host disease (GVHD) ... Cited by 1 - Related articles - All 2 versions
