- ►nih.gov S Heikkinen, J Auwerx, CA Argmann - BBA-Molecular and Cell Biology of Lipids, 2007 - Elsevier The peroxisome proliferator activated receptor gamma (PPARγ) is a member in the nuclear receptor
superfamily which mediates part of the regulatory effects of dietary fatty acids on gene
expression. As PPARγ also coordinates adipocyte differentiation, it is an important ... Cited by 52 - Related articles - All 5 versions
G Medina-Gomez, SL Gray, L Yetukuri, K … - PLoS …, 2007 - genetics.plosjournals.org Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform
of PPARg. Ablation of PPARg2 in the ob/ob background, PPARg2 −/− Lep ob /Lep ob (POKO
mouse), resulted in decreased fat mass, severe insulin resistance, β-cell failure, and ... Cited by 39 - Related articles - Cached - All 7 versions
- ►endojournals.org CA Kim, M Delepine, E Boutet, H El Mourabit, S … - Journal of Clinical …, 2008 - Endocrine Soc Results: A homozygous nonsense mutation (p.Glu38X) was identified in CAV1 in a patient with
BSCL born from a consanguineous union. This mutation affects both the - and β-CAV1 isoforms
and ablates CAV1 expression in skin fibroblasts. Detailed magnetic resonance imaging of ... Cited by 28 - Related articles - BL Direct - All 3 versions
SL Gray, AJ Vidal-Puig - Nutrition reviews, 2007 - ingentaconnect.com Adipose tissue expands to accommodate increased lipid through hypertrophy of existing adipocytes
and by initiating differentiation of preadipocytes. The ca- pacity of adipose tissue to expand is
critical for accommodating changes in energy availability, but this capacity is not an ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►nih.gov CM Halabi, AM Beyer, WJ de Lange, HL Keen, GL … - Cell metabolism, 2008 - Elsevier Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor
that plays a critical role in metabolism. Thiazolidinediones, high-affinity PPARγ ligands used
clinically to treat type II diabetes, have been reported to lower blood pressure and provide ... Cited by 14 - Related articles - All 8 versions
- ►biochemsoctrans.org SO'Rahilly - Fatty Acid and Lipotoxicity in Obesity and Diabetes, 2007 - books.google.com Human obesity and insulin resistance: lessons from experiments of nature Stephen O'Rahilly
University of Cambridge, Department of Clinical Biochemistry, Box 232, Addenbrooke's
Hospital, Hills Road, Cambridge CB2 2QR, UK Abstract. The past decade or so has seen ... Cited by 9 - Related articles - BL Direct - All 10 versions
- ►nih.gov IW Asterholm, N Halberg, PE Scherer - Drug Discovery Today: Disease Models, 2007 - Elsevier Both the disproportionate loss of adipose tissue in the case of lipodystrophies and the disproportionate
gain of adipose tissue in obesity are frequently associated with an increase in insulin resistance
and its complications. Leptin replacement is a very promising therapeutic approach for ... Cited by 8 - Related articles - All 3 versions
S Virtue, A Vidal-Puig - PLoS Biol, 2008 - biology.plosjournals.org Mechanisms underlying obesity-related metabolic disorders are poorly understood. Samuel
Virtue and Antonio Vidal-Puig explore the evidence for an emerging hypothesis that attributes
metabolic complications not to obesity per se, but to an individual's capacity for adipose ... Cited by 7 - Related articles - Cached - All 12 versions
- ►diabetesjournals.org C Lagathu, C Christodoulides, S Virtue, WP Cawthorn, … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Dact1 is a preadipocyte gene that decreases during adipogenesis. However, Dact1
knockdown impairs adipogenesis through activation of the Wnt/β-catenin signaling pathway,
and this is reversed by treatment with the secreted Wnt antagonist, secreted ... Cited by 4 - Related articles - All 4 versions
JM Guettier, JY Park, EK Cochran, C Poitou, … - Clinical …, 2008 - pubmedcentral.nih.gov Partial lipodystrophy (PL) is most commonly characterized by loss of subcutaneous fat in the
extremities with preservation of truncal fat and is associated with insulin resistance, diabetes
and hyperlipidaemia. Recombinant human leptin (rmetHuLeptin) therapy has been ... Cited by 3 - Related articles - BL Direct - All 5 versions
