ED Rosen, BM Spiegelman - Nature, 2006 - nature.com Adipocytes have been studied with increasing intensity as a result of the emergence of obesity
as a serious public health problem and the realization that adipose tissue serves as an integrator
of various physiological pathways. In particular, their role in calorie storage makes ... Cited by 227 - Related articles - BL Direct - All 6 versions
- ►physiology.org BK Pedersen, TCA Akerstrom, AR Nielsen … - Journal of Applied …, 2007 - Am Physiological Soc During the past 20 yr, it has been well documented that exercise has a profound effect on the
immune system. With the discovery that exercise provokes an increase in a number of
cytokines, a possible link between skeletal muscle contractile activity and immune ... Cited by 54 - Related articles - BL Direct - All 5 versions
AMW Petersen, BK Pedersen - Journal of Physiology and Pharmacology, 2006 - jpp.krakow.pl Regular exercise offers protection against all cause mortality and there is evidence from randomised
intervention studies that physical training is effective as a treatment in patients with chronic heart
diseases, type 2 diabetes and symptoms related to the metabolic syndrome. Chronic ... Cited by 45 - Related articles - View as HTML - All 5 versions
BK Pedersen, CP Fischer - Current Opinion in Clinical Nutrition & …, 2007 - journals.lww.com Recent findings: Contraction-induced transcription and release of interleukin-6 is primarily regulated
by an altered intramuscular milieu in response to exercise. Accordingly, changes in calcium
homeostasis, impaired glucose availability and increased formation of reactive oxygen ... Cited by 41 - Related articles - BL Direct - All 7 versions
CP Fischer - Exerc Immunol Rev, 2006 - voeljemens.nl Page 1. Interleukin-6 in acute exercise and training: what is the biological relevance?
Christian P. Fischer, MD PhD Centre of Inflammation and Metabolism, Department
of Infectious Diseases and Copenhagen Muscle Research ... Cited by 37 - Related articles - View as HTML - All 3 versions
- ►diabetesjournals.org S Glund, A Deshmukh, YC Long, T Moller, HA … - Diabetes, 2007 - Am Diabetes Assoc Interleukin (IL)-6 is a proinflammatory cytokine shown to modify insulin sensitivity. Elevated plasma
levels of IL-6 are observed in insulin-resistant states. Interestingly, plasma IL-6 levels also increase
during exercise, with skeletal muscle being the predominant source. Thus, IL-6 has also ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►physiology.org BK Pedersen, MA Febbraio - Physiological reviews, 2008 - Am Physiological Soc Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been suggested
that cytokines and other peptides that are produced, expressed, and released by muscle fibers
and exert paracrine, autocrine, or endocrine effects should be classified as "myokines." ... Cited by 31 - Related articles - All 4 versions
- ►physiology.org Y Wei, K Chen, AT Whaley-Connell, CS … - American Journal of …, 2008 - Am Physiological Soc The cardiometabolic syndrome (CMS), with its increased risk for cardiovascular disease
(CVD), nonalcoholic fatty liver disease (NAFLD), and chronic kidney disease (CKD), has become
a growing worldwide health problem. Insulin resistance is a key factor for the ... Cited by 31 - Related articles - BL Direct - All 3 versions
B Pedersen - Biochemical Society Transactions, 2007 - biochemsoctrans.org Low-grade chronic inflammation is a feature of Type 2 diabetes and appears to play a pathogenetic
role in insulin resistance. It is well known that cytokines, besides their immunoregulatory
roles, are important players in metabolism. Moreover, it has become evident that skeletal ... Cited by 29 - Related articles - Cached - BL Direct - All 5 versions
- ►nih.gov MA Febbraio - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig Obesity and its related cluster of pathophysiologic conditions including insulin resistance, glucose
intolerance, dyslipidemia, and hypertension are recognized as growing threats to world
health. It is now estimated that 10% of the world's population is overweight or obese. As a ... Cited by 26 - Related articles - BL Direct - All 7 versions
