- ►nih.gov C Handschin, CS Choi, S Chin, S Kim, D … - Journal of Clinical …, 2007 - Am Soc Clin Investig 1 Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School,
Boston, Massachusetts, USA. 2 Institute of Physiology and Zurich Center for Integrative Human
Physiology, University of Zurich, Zurich, Switzerland. 3 Howard Hughes Medical Institute ... Cited by 38 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org L Shu, NS Sauter, FT Schulthess, AV Matveyenko, J … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—To investigate the effects of TCFL7L2 depletion, isolated
islets were exposed to TCF7L2 small interfering RNA (siRNA) versus scrambled siRNA, and
β-cell survival and function were examined. For TCF7L2 overexpression, islets were ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N Billestrup, T … - Endocrine …, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro discovery in 1984, evolving
via descriptive and phenomenological studies to detailed mapping of the signalling
pathways, gene- and protein expression patterns, molecular and biochemical effector ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►pnas.org DM Schumann, K Maedler, I Franklin, D … - Proceedings of the …, 2007 - National Acad Sciences Pancreatic β cell mass and function increase in conditions of enhanced insulin demand such
as obesity. Failure to adapt leads to diabetes. The molecular mechanisms controlling this adaptive
process are unclear. Fas is a death receptor involved in β cell apoptosis or proliferation, ... Cited by 21 - Related articles - BL Direct - All 11 versions
MY Donath, DM Schumann, M Faulenbach, H … - Diabetes Care, 2008 - Am Diabetes Assoc Inflammation is defined as the local response to tissue injury. It is characterized by immune cell
invasion and local release of cytokines and chemokines and is sometimes accompanied by functional
or structural damage of the invaded tissue. It is not in itself a disease, but a manifestation ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►endojournals.org NS Sauter, FT Schulthess, R Galasso, LW Castellani, K … - Endocrinology, 2008 - Endocrine Soc Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines
impair β-cell function and survival. A recent clinical trial shows that blocking IL-1β signaling by
IL-1 receptor antagonist (IL-1Ra) improves β-cell secretory function in patients with type 2 ... Cited by 19 - Related articles - BL Direct - All 4 versions
WD'Hertog, L Overbergh, K Lage, GB Ferreira, M Maris, … - Mol. Cell. Proteomics, 2007 - ASBMB Proteomic analysis of cytokine-induced dysfunction and death in insulin ... D'Hertog W.1,*, Overbergh
L.1,*, Lage K.2, Ferreira GB1, Maris M.1 , Gysemans C.1, Flamez ... D.3, Cardozo AK3, Van den
Bergh G.4, Schoofs L.5,6, Arckens L.4,6, Moreau Y.8, Hansen Cited by 15 - Related articles - BL Direct - All 5 versions
- ►endojournals.org P Ribaux, JA Ehses, N Lin-Marq, F Carrozzino, M Boni- … - Endocrinology, 2007 - Endocrine Soc As we showed previously, the extracellular matrix (ECM) derived from rat bladder carcinoma
cells (804G-ECM) has positive effects on rat primary β-cell function and survival in vitro. The
aim of this study was to define β-cell genes induced by this ECM with a specific focus on ... Cited by 13 - Related articles - BL Direct - All 4 versions
K Maedler - Diabetes Obesity and Metabolism, 2008 - interscience.wiley.com The healthy β-cell has an enormous capacity to adapt to conditions of higher insulin demand
(eg in obesity, pregnancy, cortisol excess) to maintain normoglycaemia with an increase in its
functional β-cell mass. This compensates in 80–90% of individuals for insulin resistance. ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org T Brun, BR Gauthier - Journal of Molecular Endocrinology, 2008 - Soc Endocrinology Blood glucose homeostasis is achieved by the regulation of insulin and glucagon secretion from
the pancreatic islet β- and -cells. Diabetes mellitus, which comprises a heterogeneous group
of hyperglycaemic disorders, results mainly from inadequate mass and function of islet β- ... Cited by 5 - Related articles - All 4 versions
