- ►biologists.org LC Murtaugh - Development, 2007 - dev.biologists.org The development of insulin-producing pancreatic beta (ß)-cells represents the culmination of
a complex developmental program. Cells of the posterior foregut assume a pancreatic
identity, cells within the expanding pancreatic primordia adopt an endocrine fate, and a ... Cited by 56 - Related articles - BL Direct - All 5 versions
JM Oliver-Krasinski, DA Stoffers - Genes & development, 2008 - genesdev.cshlp.org The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and decreased
β-cell numbers, raising hope for cell replacement therapy. Although human islet transplantation
is a cell-based therapy under clinical investigation for the treatment of type 1 diabetes, the ... Cited by 21 - Related articles - All 4 versions
C Affourtit, MD Brand - BBA-Bioenergetics, 2008 - Elsevier Pancreatic beta cells secrete insulin when blood glucose levels are high. Dysfunction of this
glucose-stimulated insulin secretion (GSIS) is partly responsible for the manifestation of type
2 diabetes, a metabolic disorder that is rapidly becoming a global pandemic. ... Cited by 13 - Related articles - All 2 versions
P White, L May… - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Differentiation toward the endocrine lineage is dependent
on the transcription factor Neurogenin 3 (Neurog3, Ngn3). We utilize a Neurog3–enhanced green
fluorescent protein knock-in mouse model to isolate endocrine progenitor cells from ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►endojournals.org OT Hardy, HE Hohmeier, TC Becker, E … - Molecular …, 2007 - Endocrine Soc Recent advances in functional genomics afford the opportunity to interrogate the expression
profiles of thousands of genes simultaneously and examine the function of these genes in a
high-throughput manner. In this study, we describe a rational and efficient approach to ... Cited by 10 - Related articles - BL Direct - All 4 versions
L Partridge, JC Brüning - Oncogene, 2008 - nature.com Mutations in single genes and environmental interventions can extend healthy lifespan in laboratory
model organisms. Some of the mechanisms involved show evolutionary conservation, opening
the way to using simpler invertebrates to understand human ageing. Forkhead ... Cited by 5 - Related articles - BL Direct - All 2 versions
N Gao, J LeLay, MZ Vatamaniuk, S Rieck, JR … - Genes & …, 2008 - genesdev.cshlp.org The onset of pancreas development in the foregut endoderm is marked by activation of the homeobox
gene Pdx1 (IPF1). Pdx1 is essential for the expansion of the pancreatic primordium and the development
of endocrine islets. The control of Pdx1 expression has been only partially elucidated. We ... Cited by 3 - Related articles - All 4 versions
V Iacobazzi, V Infantino, F Bisaccia, A Castegna, F … - … and Biophysical Research …, 2009 - Elsevier In this study, we have investigated the transcriptional role of the FOXA site present in the promoter
of the mitochondrial citrate carrier (CIC) gene. We have shown that wild-type (but not
mutated) CIC FOXA site cloned in front of the luciferase promoter confers transcriptional ... Cited by 2 - Related articles - All 2 versions
S Galetti, A Sarre, H Perreten, N Produit- … - Pflügers Archiv European …, 2009 - Springer Page 1. SIGNALING AND CELL PHYSIOLOGY Fatty acids do not activate UCP2 in pancreatic
beta cells: comparison with UCP1 Sandrine Galetti & Alexandre Sarre & Hélène Perreten &
Nathalie Produit-Zengaffinen & Patrick Muzzin & Françoise Assimacopoulos-Jeannet ... Related articles - All 2 versions
- ►endojournals.org [PDF] OT Hardy, HE Hohmeier, TC Becker, E … - Molecular …, 2006 - Endocrine Soc Page 1. Functional genomics of the pancreatic β-cell Hardy et al. 1 Functional genomics
of the β-cell: SCHAD regulates insulin secretion independent of K + currents Short
Title: Functional Genomics of the Beta-Cell Olga T. Hardy ... Related articles
