- ►endojournals.org SA Kaplan, P Cohen - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Context: The somatomedin/IGF hypothesis was based on the observation that GH was inactive
when added to an in vitro incubation system but required a GH-dependent substance in the circulation
to mediate its activity. Newer experimental evidence has led to several modifications of ... Cited by 18 - Related articles - BL Direct - All 2 versions
A Bartke - Journal of Anatomy - interscience.wiley.com Growth hormone deficiency or resistance resulting from spontaneous or experimentally produced
mutations in laboratory mice delay aging and increase lifespan. Alterations in insulin-like growth
factor-1 (IGF-1) and insulin signaling emerged as likely mechanisms linking growth ... Cited by 13 - Related articles - BL Direct - All 5 versions
- ►fasebj.org FH Einstein, S Fishman, J Bauman, RF Thompson, DM … - The FASEB Journal, 2008 - FASEB Calorie restriction improves life span whereas nutrient excess leads to obesity and unfavorable
metabolic consequences, supporting the role for a cellular "nutrient sensor" in aging. Hexosamine
biosynthetic pathway (HBP) is a candidate nutrient-sensing pathway. We hypothesized ... Cited by 2 - Related articles - All 4 versions
DMR Rev - Diabetes Metab Res Rev, 2009 - assets0.pubget.com Diabetes Metab Res Rev 2009; 25: 3–12. Published online in Wiley InterScience
(www.interscience.wiley.com) DOI: 10.1002/dmrr.919 ... The role of insulin-like growth
factor-I and its ... Swapnil N. Rajpathak1* Marc J. Gunter1 Judith Wylie-Rosett1 Gloria YF ... Cited by 2 - Related articles - View as HTML - All 4 versions
RH Muzumdar, DM Huffman, G Atzmon, C Buettner, LJ … - 2009 - pubmedcentral.nih.gov Using state of the art clamp technology, we examined the role of central and peripheral HN on
insulin action. Continuous infusion of HN intra-cerebro-ventricularly significantly improved overall
insulin sensitivity. The central effects of HN on insulin action were associated with ... Cited by 1 - Related articles - All 5 versions
PM Yamada, KW Lee - American Journal of Physiology- Cell …, 2009 - Am Physiological Soc Insulin-like growth factor (IGF) binding protein (IGFBP)-3 has traditionally been defined by its
role as a binding protein and its association with IGF delivery and availability. Development of
non-IGF binding IGFBP-3 analogs and the use of cell lines devoid of type 1 IGF receptors ( ... Related articles - All 3 versions
R Muniyappa, H Chen, RH Muzumdar, FH … - American Journal of …, 2009 - Am Physiological Soc Assessing insulin resistance in rodent models gives insight into mechanisms that cause type
2 diabetes and the metabolic syndrome. The hyperinsulinemic euglycemic glucose clamp, the
reference standard for measuring insulin sensitivity in humans and animals, is labor ... Related articles - All 3 versions
MP Rozing, RGJ Westendorp, M Frölich, AJM de Craen … - AGING, 2009 - impactaging.com In Western societies, life expectancy has increased dramatically over the last century, but striking
inter- individual differences in life expectancy remain [1]. Ample evidence has shown that healthy
longevity is determined by a mix of genetic, environmental and chance elements. ... Related articles - View as HTML - All 3 versions