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Scholar Results 1 - 10 of about 14 citing Sørensen: Immunoneutralization of endogenous glucagon reduces hepatic glucose output and.... (0.07 sec) 

{alpha}-Cells of the endocrine pancreas: 35 years of research but the enigma …

- endojournals.org
J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc
Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ...
Cited by 61 - Related articles - BL Direct - All 4 versions

The role of {alpha}-cell dysregulation in fasting and postprandial hyperglycemia in …

- endojournals.org
BE Dunning, JE Gerich - Endocrine reviews, 2007 - Endocrine Soc
The hyperglycemic activity of pancreatic extracts was encountered some 80 yr ago during efforts
to optimize methods for the purification of insulin. The hyperglycemic substance was named
"glucagon," and it was subsequently determined that glucagon is a 29-amino acid peptide ...
Cited by 32 - Related articles - BL Direct - All 5 versions

The physiology of obese-hyperglycemic mice [ob/ob mice].


P Lindström - TheScientificWorldJOURNAL, 2007 - thescientificworld.com
Page 1. Review Article TheScientificWorldJOURNAL (2007) 7, 666–685 ISSN 1537-744X; DOI
10.1100/tsw.2007.117 ©2007 with author. Published by TheScientificWorld; www.
thescientificworld.com 666 The Physiology of Obese-Hyperglycemic Mice [ob/ob Mice] ...
Cited by 20 - Related articles - All 3 versions

New hepatic targets for glycaemic control in diabetes


L Agius - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier
Type-2 diabetes is associated with impaired glucose clearance by the liver in the postprandial
state, and with elevated glucose production in the post-absorptive state. New targets within the
liver are currently being investigated for development of antihyperglycaemic drugs for ...
Cited by 17 - Related articles - All 17 versions

Physiology of the pancreatic {alpha}-cell and glucagon secretion: role in glucose …

- endocrinology-journals.org
I Quesada, E Tuduri, C Ripoll, A Nadal - Journal of Endocrinology, 2008 - Soc Endocrinology
The secretion of glucagon by pancreatic -cells plays a critical role in the regulation of
glycaemia. This hormone counteracts hypoglycaemia and opposes insulin actions by stimulating
hepatic glucose synthesis and mobilization, thereby increasing blood glucose ...
Cited by 8 - Related articles - All 3 versions

A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in …

- shouxi.net
RD Wideman, SD Covey, GC Webb, DJ Drucker, TJ … - Diabetes, 2007 - Am Diabetes Assoc
OBJECTIVE—Glucagon, which raises blood glucose levels by stimulating hepatic glucose
production, is produced in α-cells via cleavage of proglucagon by prohormone convertase
(PC)-2. In the enteroendocrine L-cell, proglucagon is differentially processed by the ...
Cited by 5 - Related articles - BL Direct - All 5 versions

Targeting glucagon receptor signalling in treating metabolic syndrome and renal …


C Xiao… - Clinical science (London, England: 1979), 2007 - pubmedcentral.nih.gov
Pancreatic bi-hormones insulin and glucagon are the Yin and Yang in the regulation of glucose
metabolism and homoeostasis. Insulin is synthesized primarily by pancreatic β-cells and is released
in response to an increase in blood glucose levels (hyperglycaemia). By contrast, ...
Cited by 3 - Related articles - BL Direct - All 9 versions

Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve …


H Yan, W Gu, J Yang, V Bi, Y Shen, E Lee, KA … - Journal of Pharmacology …, 2009 - ASPET
Antagonizing the glucagon signaling pathway represents an attractive therapeutic approach
for reducing excess hepatic glucose production in patients with type 2 diabetes. Despite extensive
efforts, there is currently no human therapeutic that directly inhibits the ...
Cited by 2 - Related articles - All 4 versions

A Switch from PC2 to PC1/3 Expression in Transplanted α-cells is Accompanied by …

- diabetesjournals.org [PDF] 
RD Wideman, SD Covey, GC Webb, DJ Drucker, TJ … - Diabetes, 2007 - Am Diabetes Assoc
Running Title: Transplantation of PC2- or PC1/3-expressing α-cells ... 2350 Health Sciences
Mall, Vancouver, British Columbia, V6T 1Z3 Email: tim.kieffer@ubc.ca ... Received for publication
23 April 2007 and accepted in revised form 6 August 2007. ... 1 Laboratory of Molecular ...
Cited by 2 - Related articles - All 2 versions

Cortistatin vaccination–A solution to growth hormone deficiency


M Moaeen-ud-Din, N Malik, YL Guo, ME Babar, A Ali - Medical Hypotheses, 2009 - Elsevier
Cortistatin and somatostatin are neuropeptides which have inhibitory effects on growth hormone
through common five receptors. Although, both have inhibitory effects but, only cortistatin has
direct inhibitory effects on growth hormone secretagogue and is more potent inhibitor of ...
Related articles - All 2 versions


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