PC Butler, JJ Meier, AE Butler, A Bhushan - Nature clinical practice. …, 2007 - ncbi.nlm.nih.gov Replication of beta cells is an important source of beta-cell expansion in early childhood. The
recent linkage of type 2 diabetes with several transcription factors involved in cell cycle regulation
implies that growth of the beta-cell mass in early childhood might be an important ... Cited by 42 - Related articles - BL Direct - All 3 versions
- ►endocrinology-journals.org AM Ackermann, M Gannon - Journal of molecular endocrinology, 2007 - Soc Endocrinology Pancreatic ß-cells are responsible for producing all of the insulin required by an organism to
maintain glucose homeostasis. Defects in development, maintenance, or expansion of ß-cell
mass can result in impaired glucose metabolism and diabetes. Thus, identifying the ... Cited by 37 - Related articles - All 4 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N Billestrup, T … - Endocrine …, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro discovery in 1984, evolving
via descriptive and phenomenological studies to detailed mapping of the signalling
pathways, gene- and protein expression patterns, molecular and biochemical effector ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org DA Cano, IC Rulifson, PW Heiser, LB Swigart, S … - Diabetes, 2008 - Am Diabetes Assoc Several studies have shown that the adult pancreas possesses a limited potential for β-cell regeneration
upon tissue injury. One of the difficulties in studying β-cell regeneration has been the lack of
a robust, synchronized animal model system that would allow controlled regulation of ... Cited by 15 - Related articles - BL Direct - All 3 versions
- ►nih.gov L Zhong, S Georgia, S Tschen, K … - Journal of Clinical …, 2007 - Am Soc Clin Investig Diabetes results from an inadequate mass of functional β cells, due to either β cell loss caused
by immune assault or the lack of compensation to overcome insulin resistance. Elucidating the
mechanisms that regulate β cell mass has important ramifications for fostering β cell ... Cited by 11 - Related articles - BL Direct - All 7 versions
- ►nih.gov S Dhawan, S Georgia, A Bhushan - Current opinion in cell biology, 2007 - Elsevier The elaboration of the pancreas from epithelial buds to the intricate organ requires complex patterning
information that controls fundamental cellular processes such as differentiation and proliferation
of pancreatic progenitor cells. During pancreatic organogenesis, endocrine cells are ... Cited by 9 - Related articles - All 5 versions
- ►nih.gov JC Schisler, PT Fueger, DA Babu, HE … - Molecular and cellular …, 2008 - Am Soc Microbiol The homeodomain transcription factor Nkx6.1 plays an important role in pancreatic islet β-cell
development, but its effects on adult β-cell function, survival, and proliferation are not well
understood. In the present study, we demonstrated that treatment of primary rat pancreatic ... Cited by 4 - Related articles - BL Direct - All 7 versions
J Chen, Y Lu, CH Lee, R Li, EH Leiter, CE … - Free Radical Biology and …, 2008 - Elsevier ALR/Lt, a NOD-related mouse strain, was selected for resistance to alloxan free radical-mediated
diabetes (ALD). Despite extensive genomic identity with NOD (> 70%), ALR mice display strong
resistance to autoimmune type 1 diabetes (T1D) due to both an unusual elevation in ... Cited by 4 - Related articles - All 3 versions
M Hermann, R Margreiter, P Hengster - Journal of Cellular and Molecular …, 2007 - duke.edu Human islet transplantation could represent an attractive alternative to insulin injections for the
treatment of dia- betes type 1. However, such an approach requires a better understanding of
the molecular and cellular switch- es controlling ß-cell function in general as well as after ... Cited by 5 - Related articles - View as HTML - BL Direct - All 4 versions
