- ►diabetesjournals.org Q Ouyang, NE Standifer, H Qin, P Gottlieb, … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes results from the autoimmune destruction of insulin-producing
pancreatic β-cells by cytotoxic T-lymphocytes (CTLs). In humans, few β-cell
epitopes have been reported, thereby limiting the study of ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Mallone, E Martinuzzi, P Blancou, G Novelli … - Diabetes, 2007 - Am Diabetes Assoc Despite the understanding that type 1 diabetes pathogenesis is mediated by
T-cells, detection of these rare lymphocytes remains largely elusive. Suitable
T-cell assays are highly needed, since they could offer preclinical ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org E Martinuzzi, G Novelli, M Scotto, P Blancou, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—CD8 + T-cell reactivities were less frequent at follow-up, as 28.6% of
responses tested positive at type 1 diabetes diagnosis vs. 13.2% after a median
of 11 months (P = 0.003). While GAD and IA-2 autoantibody (aAb) titers were ... Cited by 11 - Related articles - BL Direct - All 9 versions
SL Manuel, S Rahman, B Wigdahl, ZK Khan, P … - Frontiers in Bioscience, 2007 - bioscience.org 1. Abstract 2. Introduction 3. Rheumatic diseases and dendritic cells (DCs) 3.1.
Psoriasis 3.2. Rheumatoid arthritis 3.3. Systemic lupus erythematosus 3.4.
Sjögren's syndrome 4. Diabetes and DCs 5.Neuroinflammatory diseases and ... Cited by 11 - Related articles - View as HTML - All 3 versions
- ►jimmunol.org P Blancou, R Mallone, E Martinuzzi, S Severe … - The Journal of Immunology, 2007 - Am Assoc Immnol Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic
cells. CD8 + T cells have recently been assigned a major role in cell injury.
Consequently, the identification of autoreactive CD8 + T cells in humans ... Cited by 10 - Related articles - All 6 versions
- ►diabetesjournals.org I Jarchum, JC Baker, T Yamada, T Takaki, MP … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—We found that HLA-A*0201-restricted T-cells isolated from the islets
of the transgenic mice were specific for Ins1 L3–11, Ins1 B5–14, and Ins1/2
A2–10. Insulin-reactive T-cells were present in the islets of mice as ... Cited by 10 - Related articles - BL Direct - All 4 versions
A Skowera, RJ Ellis, R Varela-Calviño, S … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Ania Skowera,1,2 Richard J. Ellis,1 Ruben Varela-Calviño,3 Sefina Arif,1 Guo
Cai Huang,4 Cassie Van-Krinks,1 Anna Zaremba,1 Chloe Rackham,1 Jennifer S.
Allen,1 Timothy IM Tree,1 Min Zhao,4 Colin M. Dayan,5 Andrew K. Sewell,6 ... Cited by 9 - Related articles - All 11 versions
- ►nih.gov I Jarchum, L Nichol, M Trucco, P Santamaria, … - Clinical Immunology, 2008 - Elsevier CD8 + T cells play an important role in the development of type 1 diabetes (T1D)
in NOD mice and humans. IGRP (islet-specific glucose-6-phosphatase catalytic
subunit-related protein) has emerged in recent years as a major antigen in ... Cited by 7 - Related articles - All 3 versions
C Baker, LG Petrich de Marquesini, AJ … - Journal of Clinical Immunology, 2008 - Springer Abstract Purpose In this study, we explored the breadth of CD8 T cell reactivity
to preproinsulin (PPI) in type 1 diabetes. Materials and Methods We tested a
complete peptide set in pools covering all 406 potential 8–11mer epitopes ... Cited by 6 - Related articles - All 2 versions
H Tsui, S Winer, Y Chan, D Truong, L Tang, J … - System, 1927 - interscience.wiley.com Type 1 diabetes (T1D) is caused by autoimmune β cell destruction. The early
events triggering T1D and the forces that keep diabetic autoimmunity pancreas
specific have been unclear. Our discovery that autoimmune islet destruction ... Cited by 4 - Related articles - All 4 versions
