- ►endojournals.org GS Eisenbarth - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Synthesis: There has been recent progress in defining the genetics,
pathogenesis, and natural history of the disease. In addition, there is a major
effort to develop immunotherapies to prevent the disorder and to cure the ... Cited by 30 - Related articles - All 3 versions
- ►diabetesjournals.org R Mallone, E Martinuzzi, P Blancou, G Novelli … - Diabetes, 2007 - Am Diabetes Assoc Despite the understanding that type 1 diabetes pathogenesis is mediated by
T-cells, detection of these rare lymphocytes remains largely elusive. Suitable
T-cell assays are highly needed, since they could offer preclinical ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org NE Standifer, Q Ouyang, C Panagiotopoulos, … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocytes (CTLs) are considered to be essential for β-cell
destruction in type 1 diabetes. However, few islet-associated peptides have been
demonstrated to activate autoreactive CTLs from type 1 diabetic subjects. ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►nih.gov M Nakayama, JN Beilke, JM Jasinski, M … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig NOD mice with knockout of both native insulin genes and a mutated proinsulin
transgene, alanine at position B16 in preproinsulin (B16:A-dKO mice), do not
develop diabetes. Transplantation of NOD islets, but not bone marrow, ... Cited by 15 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org E Martinuzzi, G Novelli, M Scotto, P Blancou, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—CD8 + T-cell reactivities were less frequent at follow-up, as 28.6% of
responses tested positive at type 1 diabetes diagnosis vs. 13.2% after a median
of 11 months (P = 0.003). While GAD and IA-2 autoantibody (aAb) titers were ... Cited by 12 - Related articles - BL Direct - All 9 versions
- ►jimmunol.org P Blancou, R Mallone, E Martinuzzi, S Severe … - The Journal of Immunology, 2007 - Am Assoc Immnol Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic
cells. CD8 + T cells have recently been assigned a major role in cell injury.
Consequently, the identification of autoreactive CD8 + T cells in humans ... Cited by 10 - Related articles - All 6 versions
- ►diabetesjournals.org I Jarchum, JC Baker, T Yamada, T Takaki, MP … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—We found that HLA-A*0201-restricted T-cells isolated from the islets
of the transgenic mice were specific for Ins1 L3–11, Ins1 B5–14, and Ins1/2
A2–10. Insulin-reactive T-cells were present in the islets of mice as ... Cited by 10 - Related articles - BL Direct - All 4 versions
SC Almo, JB Bonanno, JM Sauder, S Emtage, … - Journal of Structural and Functional Genomics, 2007 - Springer Abstract The New York SGX Research Center for Structural Genomics (NYSGXRC) of
the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-
ray crystallographic structure determination platform to systematic studies ... Cited by 9 - Related articles - BL Direct - All 3 versions
- ►nih.gov I Jarchum, L Nichol, M Trucco, P Santamaria, … - Clinical Immunology, 2008 - Elsevier CD8 + T cells play an important role in the development of type 1 diabetes (T1D)
in NOD mice and humans. IGRP (islet-specific glucose-6-phosphatase catalytic
subunit-related protein) has emerged in recent years as a major antigen in ... Cited by 7 - Related articles - All 3 versions
C Baker, LG Petrich de Marquesini, AJ … - Journal of Clinical Immunology, 2008 - Springer Abstract Purpose In this study, we explored the breadth of CD8 T cell reactivity
to preproinsulin (PPI) in type 1 diabetes. Materials and Methods We tested a
complete peptide set in pools covering all 406 potential 8–11mer epitopes ... Cited by 6 - Related articles - All 2 versions
