K Shimomura, F Horster, H de Wet, SE Flanagan … - Neurology, 2007 - AAN Enterprises Objectives: Activating mutations in the human KCNJ11 gene, encoding the
pore-forming subunit (Kir6.2) of the ATP-sensitive potassium (K ATP ) channel,
are one cause of neonatal diabetes mellitus. In a few patients, KCNJ11 ... Cited by 15 - Related articles - All 4 versions
- ►physiology.org FM Ashcroft - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc This essay is based on a lecture given to the American Physiological Society in
honor of Walter B. Cannon, an advocate of homeostasis. It focuses on the role of
the ATP-sensitive potassium K + (K ATP ) channel in glucose homeostasis ... Cited by 12 - Related articles - BL Direct - All 2 versions
- ►nih.gov K Tsaneva-Atanasova, CL Zimliki, R Bertram, … - Biophysical journal, 2006 - Elsevier Cell coupling is important for the normal function of the β-cells of the
pancreatic islet of Langerhans, which secrete insulin in response to elevated
plasma glucose. In the islets, electrical and metabolic communications are ... Cited by 12 - Related articles - BL Direct - All 21 versions
H de Wet, MG Rees, K Shimomura, J … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Gain-of-function mutations in the genes encoding the ATP-sensitive potassium (K
ATP ) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) are a common cause of
neonatal diabetes mellitus. Here we investigate the molecular mechanism by ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►nih.gov ME Meyer-Hermann - Biophysical Journal, 2007 - Elsevier The electrophysiology of β-cells is at the origin of insulin secretion.
β-Cells exhibit a complex behavior upon stimulation with glucose including
repeated bursts and continuous spiking. Mathematical modeling is most ... Cited by 5 - Related articles - BL Direct - All 11 versions
P Tammaro, 2007 - content.karger.com Abstract: ATP-sensitive potassium (K ATP ) channels are inhibited by
intracellular ATP and activated by MgADP. As a consequence, they couple the
metabolic state of the cell to its electrical activity. In pancreatic ... Cited by 2 - Related articles - BL Direct - All 2 versions
AI Tarasov, CA Girard, B Larkin, P Tammaro, … - Diabetes Obes Metab, 2007 - interscience.wiley.com Heterozygous activating mutations in Kir6.2 (KCNJ11), the pore-forming subunit
of the adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channel, are a
common cause of neonatal diabetes (ND). We assessed the functional effects ... Cited by 2 - Related articles - All 2 versions
M van de Bunt, AL Gloyn - Personalized Medicine, 2007 - Future Medicine Over the past 10–20 years, our understanding of the genetic etiology of
monogenic disorders of the pancreatic β-cell has greatly improved. This has
enabled clinicians to provide patients with more accurate information ... Cited by 1 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] AI Tarasov, T Nicolson, JP Riveline, TK … - Diabetes, 2008 - Am Diabetes Assoc Page 1. A rare mutation in ABCC8/SUR1 leading to altered K ATP channel activity
and β-cell glucose sensing is associated with type ... Cited by 1 - Related articles - All 2 versions
AI Tarasov, TJ Nicolson, JP Riveline, TK … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— A mutation in ABCC8/SUR1, leading to a Y356C substitution in the
seventh membrane-spanning α-helix, was observed in a patient diagnosed with
hyperglycemia at age 39 years and in two adult offspring with impaired ... Cited by 1 - Related articles - All 4 versions
