MK Badman, JS Flier - Gastroenterology, 2007 - Elsevier Obesity is responsible for the mounting incidence of metabolic disease in adult and pediatric
populations. Understanding of the pathogenesis and maintenance of the obese state has advanced
rapidly over the past 10 years. Bodily energy reserves are managed actively by complex ... Cited by 61 - Related articles - All 22 versions
- ►endojournals.org RS Ahima, MA Lazar - Molecular Endocrinology, 2008 - Endocrine Soc Adipokines are secreted by adipose tissue and control various physiological systems. Low leptin
levels during fasting stimulate feeding, reduce energy expenditure, and modulate neuroendocrine
and immune function to conserve energy stores. On the other hand, rising leptin levels in ... Cited by 40 - Related articles - BL Direct - All 8 versions
Y Imai, GM Varela, MB Jackson, MJ Graham, RM … - Gastroenterology, 2007 - Elsevier Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive
triglyceride accumulation in hepatocytes. Expression of the lipid droplet protein adipose
differentiation-related protein (ADRP) is increased in NAFLD, but whether this is causally ... Cited by 31 - Related articles - All 24 versions
D Lann, D LeRoith - Medical Clinics of North America, 2007 - Elsevier Classically, the metabolic syndrome is characterized as group of pathologies including visceral
obesity, hypertension, dyslipidemia, and impaired glucose tolerance. It is now realized that insulin
resistance plays a principal role in initiating and perpetuating the pathologic ... Cited by 26 - Related articles - All 25 versions
- ►endojournals.org FF Chehab - Endocrinology, 2008 - Endocrine Soc Adipose tissue is unique in that it can undergo significant hypertrophy and atrophy, resulting
in wide ranges of obesities and lipodystrophies. At the base of this elasticity is the lipid-filled
adipocyte, which can either overfill by storing large amounts of triglycerides or shrink to a ... Cited by 16 - Related articles - BL Direct - All 7 versions
Y Guan, CL Myers, R Lu, IR Lemischka, … - PLoS Computational …, 2008 - pubmedcentral.nih.gov Establishing a functional network is invaluable to our understanding of gene function,
pathways, and systems-level properties of an organism and can be a powerful resource in directing
targeted experiments. In this study, we present a functional network for the laboratory ... Cited by 12 - Related articles - All 7 versions
- ►jneurosci.org NS Singhal, MA Lazar, RS Ahima - Journal of Neuroscience, 2007 - Soc Neuroscience Sensing of peripheral hormones and nutrients by the hypothalamus plays an important role in
maintaining peripheral glucose homeostasis. The hormone resistin impairs the response to insulin
in liver and other peripheral tissues. Here we demonstrate that in normal mice resistin ... Cited by 11 - Related articles - All 3 versions
M Qatanani, NR Szwergold, DR Greaves, … - The Journal of …, 2009 - pubmedcentral.nih.gov Resistin is an adipokine that contributes to insulin resistance in mice. In humans, however, studies
investigating the link between resistin and metabolic disease are conflicting. Further complicating
the matter, human resistin is produced mainly by macrophages rather than adipocytes. To ... Cited by 11 - Related articles - All 6 versions
- ►endojournals.org S Park, SM Hong, SR Sung, HK Jung - Endocrinology, 2008 - Endocrine Soc To determine the long-term effect of central leptin and resistin on energy homeostasis, peripheral
insulin resistance, and β-cell function and mass, intracerebroventricular (ICV) infusion of leptin
(3 ng/h), resistin (80 ng/h), leptin plus resistin, and cerebrospinal fluid (control) was ... Cited by 9 - Related articles - BL Direct - All 5 versions
