- ►nih.gov JD Lambeth - Free Radical Biology and Medicine, 2007 - Elsevier Reactive oxygen species (ROS) are considered to be chemically reactive with and
damaging to biomolecules including DNA, protein, and lipid, and excessive
exposure to ROS induces oxidative stress and causes genetic mutations. ... Cited by 81 - Related articles - All 5 versions
N Das Evcimen, GL King - Pharmacological research, 2007 - Elsevier Diabetes mellitus is a chronic disease caused by inherited and/or acquired
deficiency in production of insulin by the pancreas, and by resistance to
insulin's effects. Such a deficiency results in increased concentrations of ... Cited by 64 - Related articles - All 4 versions
RA Kowluru, PS Chan - Exp Diabetes Res, 2007 - downloads.hindawi.com Oxygen metabolism is essential for sustaining aerobic life, and normal cellular
homeostasis works on a fine balance between the formation and elimination of
reactive oxygen species (ROS). Oxidative stress, a cytopathic consequence ... Cited by 30 - Related articles - View as HTML - All 13 versions
JD Lambeth, KH Krause, RA Clark - Seminars in Immunopathology, 2008 - Springer Abstract The members of the NOX/DUOX family of NADPH oxidases mediate such
physiologic functions as host defense, cell signaling, and thyroid hormone
biosyn- thesis through the generation of reactive oxygen species (ROS), ... Cited by 14 - Related articles - All 2 versions
A Tojo, K Asaba, ML Onozato - Expert Opinion on Therapeutic Targets, 2007 - informahealthcare.com Renal nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase
is an important source of oxidative stress and its expression is enhanced in the
glomerulus and distal tubules of diabetic nephropathy. High glucose-induced ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►physiology.org L Xia, H Wang, S Munk, H Frecker, HJ … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc Vascular endothelial growth factor (VEGF) is implicated in the development of
proteinuria in diabetic nephropathy. High ambient glucose present in diabetes
stimulates VEGF expression in several cell types, but the molecular ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org ML Brezniceanu, F Liu, CC Wei, I Chénier, N … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—db/db mice developed obesity, hyperglycemia, hypertension, and
albuminuria. In contrast, db/db rCAT-Tg mice became obese and hyperglycemic but
had normal blood pressure and attenuated albuminuria compared with db/db ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►crossfitdental.com [PDF] GL King - Journal of Periodontology, 2008 - Am Acad Periodontology The prevalence of diabetes worldwide is increasing rapidly in association with
the increase in obesity. Complications are a major fear of patients with
diabetes. Complications of diabetes affect many tissues and organs, causing ... Cited by 15 - Related articles - All 5 versions
C Hernández, R Simó - Expert Opinion in Investigational Drugs, 2007 - informahealthcare.com Proliferative diabetic retinopathy (PDR) demands both more effective and less
expensive biologically based treatments. Our understanding of the
pathophysiology of the disease is increasing as new biochemical pathways ... Cited by 10 - Related articles - BL Direct - All 5 versions
P Boor, K Sebekova, T Ostendorf, J Floege - Nephrology Dialysis Transplantation, 2007 - ERA-EDTA Mechanisms contributing to tubulointerstitial injury and tubular atrophy include
glomerular proteinuria, chronic hypoxia, misdirected glomerular ultrafiltration,
tubular protein leakage and direct toxic insults of eg drugs (reviewed in ... Cited by 10 - Related articles - BL Direct - All 6 versions
