- ►diabetesjournals.org C Evans-Molina, JC Garmey, R Ketchum, KL … - Diabetes, 2007 - Am Diabetes Assoc Glucose is the primary regulator of insulin granule release from pancreatic
islets. In rodent islets, the role of glucose in the acute regulation of insulin
gene transcription has remained unclear, primarily because the abundance ... Cited by 9 - Related articles - BL Direct - All 6 versions
K Docherty, AS Bernardo, L Vallier - Seminars in Cell and Developmental Biology, 2007 - Elsevier There is a compelling need to develop novel therapies for diabetes mellitus.
Recent successes in the transplantation of islets of Langerhans are seen as a
major breakthrough. However, there is huge disparity between potential ... Cited by 8 - Related articles - All 2 versions
TG Deering, T Ogihara, AP Trace, B Maier, RG … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Within the pancreas, Set7/9 protein shows striking specificity for
islet cells, including α- and β-cells, as well as occasional cells within
ducts. Consistent with these findings, the Set7/9 gene promoter contained ... Cited by 7 - Related articles - All 3 versions
S Schinner, R Kratzner, D Baun… - Br J Pharmacol, 2009 - interscience.wiley.com Background and purpose: The transcription factor peroxisome
proliferator-activated receptor γ (PPARγ) is essential for glucose
homeostasis. PPARγ ligands reducing insulin levels in vivo are used as ... Cited by 5 - Related articles - All 3 versions
CW Hay, LA Ferguson, K Docherty - BBA-Gene Structure and Expression, 2007 - Elsevier The insulin promoter contains a number of dissimilar cis-acting regulatory
elements that bind a range of tissue specific and ubiquitous transcription
factors. Of the regulatory elements within the insulin promoter, the cyclic ... Cited by 4 - Related articles - All 3 versions
- ►nih.gov DA Babu, SK Chakrabarti, JC Garmey, RG … - Journal of Biological Chemistry, 2008 - ASBMB The activity of the insulin gene, Ins, in islet β cells is thought to arise in
part from the synergistic action of the transcription factors Pdx1 and
BETA2/NeuroD1. We asked how the binding of these factors to A and E ... Cited by 4 - Related articles - All 4 versions
- ►snmjournals.org JH Tai, B Nguyen, RG Wells, MS Kovacs, R … - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med We are combining nuclear medicine with molecular biology to establish a
sensitive, quantitative, and tomographic method with which to detect gene
expression in pancreatic islet cells in vivo. Dual-isotope SPECT can be ... Cited by 3 - Related articles - BL Direct - All 4 versions
- ►nih.gov BR Burkhardt, JR Cook, RA Young, BA Wolf - BBA-Gene Regulatory Mechanisms, 2008 - Elsevier Pancreatic Derived Factor (PANDER) is a novel cytokine-like protein dominantly
expressed within the endocrine pancreas. Our previous study demonstrated that
the PANDER promoter was both tissue-specific and glucose-responsive. ... Cited by 2 - Related articles - All 3 versions
- ►nih.gov Y Yang, BHJ Chang, SL Samson, MV Li, L … - Nucleic Acids Research, 2009 - Oxford Univ Press Glis3 is a member of the Krüppel-like family of transcription factors and is
highly expressed in islet β cells. Mutations in GLIS3 cause the syndrome of
neonatal diabetes and congenital hypothyroidism (NDH). Our aim was to ... Cited by 2 - Related articles - All 6 versions
R Watanabe, ZP Shen, K Tsuda, Y Yamada - Biochemical and Biophysical Research …, 2008 - Elsevier Activins regulate pancreatic development, differentiation and insulin secretion.
Activin receptor-like kinase 7 (ALK7) has been identified as a receptor for
Nodal and Activin AB and B, and is expressed in pancreatic islets and ... Cited by 1 - Related articles - All 3 versions
