- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►endojournals.org D Scheuner, RJ Kaufman - Endocrine Reviews, 2008 - Endocrine Soc The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized
proteins destined for the cell surface or released into the extracellular milieu. The study of protein
folding and trafficking within the ER is an extremely active area of research that has ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell …, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the
molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in ... Cited by 23 - Related articles - All 5 versions
- ►nih.gov T Otonkoski, H Jiao, N Kaminen-Ahola, I Tapia- … - The American Journal of …, 2007 - Elsevier Exercise-induced hyperinsulinism (EIHI) is a dominantly inherited hypoglycemic disorder characterized
by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. We aimed
to identify the molecular basis of this novel disorder of β-cell regulation. EIHI mapped to ... Cited by 20 - Related articles - BL Direct - All 12 versions
- ►pnas.org H Ellingsgaard, JA Ehses, EB Hammar, L … - Proceedings of the …, 2008 - National Acad Sciences Interleukin-6 (IL-6) is systemically elevated in obesity and is a predictive factor to develop type
2 diabetes. Pancreatic islet pathology in type 2 diabetes is characterized by reduced β-cell function
and mass, an increased proportion of α-cells relative to β-cells, and α-cell dysfunction. ... Cited by 6 - Related articles - All 8 versions
Y Shimizu, LM Hendershot - Antioxidants & redox signaling, 2009 - liebertonline.com All eukaryotic cells possess an endoplasmic reticulum (ER), which is the site for synthesizing
proteins that populate the cell surface or extracellular space. The environment of the ER is
oxidizing, which supports the formation of intra- and interchain disulfide bonds that serve ... Cited by 5 - Related articles - All 4 versions
Y Shimizu, LM Hendershot - ANTIOXIDANTS & REDOX SIGNALING, 2009 - liebertonline.com All eukaryotic cells possess an endoplasmic reticulum (ER), which is the site for synthesizing
proteins that populate the cell surface or extracellular space. The environment of the ER is
oxidizing, which supports the formation of intra- and interchain disulfide bonds that serve ... Related articles
M Boni-Schnetzler, S Boller, S Debray, K Bouzakri, DT … - Endocrinology, 2009 - Endocrine Soc Division of Endocrinology, Diabetes, and Nutrition (MB-S., SB, DTM, RP, JAE, MYD) and Center
for Integrated Human Physiology, University Hospital Zurich, CH-8091 Zurich, Switzerland; Gene
Expression Unit (SD, FCS), Department of Molecular Cell Biology, Katholieke Universiteit ... Related articles - All 2 versions
I Van Vaerenbergh, L Van Lommel, V Ghislain, P In't … - Human Reproduction, 2009 - ESHRE BACKGROUND: Previously, advanced endometrial maturation on the day of oocyte retrieval
in GnRH antagonist and -agonist IVF cycles was observed. In these cycles, endometrial advancement
exceeding 3 days between the histological dating and the cycle day never resulted in an ... Related articles - All 6 versions
