N Oshiro, R Takahashi, K Yoshino, K … - Journal of Biological Chemistry, 2007 - ASBMB The proline-rich Akt substrate of 40 kilodaltons (PRAS40) was identified as a
raptor-binding protein that is phosphorylated directly by mammalian target of
rapamycin (mTOR) complex 1 (mTORC1) but not mTORC2 in vitro, predominantly ... Cited by 46 - Related articles - All 6 versions
- ►nih.gov DM Ouwens, M Diamant, M Fodor, DDJ Habets, … - Diabetologia, 2007 - Springer Page 1. ARTICLE Cardiac contractile dysfunction in insulin-resistant rats fed
a high-fat diet is associated with elevated CD36-mediated ... Cited by 21 - Related articles - BL Direct - All 8 versions
- ►diabetesresearch.org [PDF] A Fornoni, A Pileggi, RD Molano, NY Sanabria, … - Diabetologia, 2008 - Springer Page 1. ARTICLE Inhibition of c-jun N terminal kinase (JNK) improves functional
beta cell mass in human islets and leads to AKT and ... Cited by 15 - Related articles - BL Direct - All 3 versions
- ►physiology.org H Alkhateeb, A Chabowski, JFC Glatz, JFP … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc We examined, in soleus muscle, the effects of prolonged palmitate exposure (0,
6, 12, 18 h) on insulin-stimulated glucose transport, intramuscular lipid
accumulation and oxidation, activation of selected insulin-signaling ... Cited by 13 - Related articles - BL Direct - All 6 versions
- ►jbc.org L Wang, TE Harris, JC Lawrence Jr - Journal of Biological Chemistry, 2008 - ASBMB The rapamycin-sensitive mammalian target of rapamycin (mTOR) complex 1 (mTORC1)
contains mTOR, raptor, mLST8, and PRAS40 (proline-rich Akt substrate of 40 kDa).
PRAS40 functions as a negative regulator when bound to mTORC1, and it ... Cited by 13 - Related articles - All 4 versions
IM Jazet, G Schaart, A Gastaldelli, E … - Diabetologia, 2008 - Springer Page 1. ARTICLE Loss of 50% of excess weight using a very low energy diet
improves insulin-stimulated glucose disposal and skeletal ... Cited by 11 - Related articles - BL Direct - All 2 versions
N Oshiro, R Takahashi, KI Yoshino, K … - J Biol Chem, 2007 - ASBMB From the ‡ Biosignal Research Center, Kobe University, Kobe 657-8501, Japan,
the ... 1 To whom correspondence should be addressed: Diabetes Research Lab,
Department of Molecular Biology, Massachusetts General Hospital, 185 ... Cited by 6 - Related articles - All 2 versions
- ►endojournals.org I Tabbi-Anneni, J Buchanan, RC Cooksey, ED … - Endocrinology, 2008 - Endocrine Soc The goal of this study was to determine whether inhibiting the renin-angiotensin
system would restore insulin signaling and normalize substrate use in hearts
from obese ob/ob mice. Mice were treated for 4 wk with Captopril (4 ... Cited by 6 - Related articles - All 4 versions
F Yu, P Narasimhan, A Saito, J Liu, PH Chan - Journal of cerebral blood flow and metabolism: official …, 2008 - pubmedcentral.nih.gov The serine-threonine kinase, Akt, plays an important role in the cell survival
signaling pathway. A proline-rich Akt substrate, PRAS40, has been characterized,
and an increase in phospho-PRAS40 (pPRAS40) is neuroprotective after ... Cited by 4 - Related articles - BL Direct - All 4 versions
- ►uoguelph.ca [PDF] KL Mullen, J Pritchard, I Ritchie, LA Snook, … - … Journal of Physiology- Regulatory, Integrative and …, 2009 - Am Physiological Soc High-fat (HF) diets can induce insulin resistance (IR) by altering skeletal
muscle lipid metabolism. An imbalance between fatty acid (FA) uptake and
oxidation results in intramuscular lipid accumulation, which can impair the ... Cited by 5 - Related articles - All 4 versions
