- ►nih.gov DD Lee, E Grossman, AS Chong - Hormone and Metabolic …, 2008 - thieme-connect.com Type 1 diabetes mellitus (T1DM) is a disease that results from the selective autoimmune destruction
of insulin-producing β-cells. This disease process lends itself to cellular therapy because of the
single cell nature of insulin production. Murine models have provided opportunities for the ... Cited by 8 - Related articles - BL Direct - All 3 versions
S Porat, Y Dor - Current Diabetes Reports, 2007 - Springer In both type 1 and type 2 diabetes, insufficient numbers of insulin-producing cells are a major
cause of defec- tive control of blood glucose and its complications. Accordingly, therapies that
increase functional -cell mass may offer a cure for diabetes. Efforts to achieve this goal ... Cited by 3 - Related articles - BL Direct - All 2 versions
- ►faustmanlab.com [PDF] A Lonyai, S Kodama, D Burger, M Davis, … - Hormone and …, 2008 - thieme-connect.com The spleen of human adults uniquely possesses a reservoir of multilineage adult stem cells that
express the developmental transcription factor Hox11. In contrast to hematopoietic stem
cells, Hox11+ stem cells hold potentially broader therapeutic applications because they ... Cited by 1 - Related articles - BL Direct - All 4 versions
GA Behr, EG da Silva, AR Ferreira, CTS … - Fundamental & …, 2008 - interscience.wiley.com The aim of this study was to investigate biochemical and antioxidant parameters in alloxan-resistant
(ALR) and alloxan-susceptible (ALS) rats. Diabetes was induced in 60-day-old male Wistar rats
by a single intraperitonial injection of alloxan (AL, 150 mg/kg). Ten days after induction, a ... Related articles - All 3 versions
T Otonkoski, M Banerjee, K Lundin - Pancreatic Beta Cell in Health and …, 2007 - Springer Summary. Clinical islet transplantation trials have shown that it is possible to at least partially
restore functional beta-cell mass in type 1 diabetic patients. However, the scarcity of organ donors
and need for intensive immunosup- pression prevent the widespread use of this treatment ... Related articles - All 2 versions
N SACHEwSKY, CM Morshead - Emerging Technology Platforms for …, 2009 - books.google.com 6 ADULT STEM CELLS AND THEIR ROLE IN ENDOGENOUS TISSUE REPAIR NADIA SACHEwSKY1
'Institute of Medical Sciences, University of Toronto, Toronto, Ontario CINDI M. MORSHEAD2
^ Department of Surgery, Division of Anatomy, University of Toronto, Toronto, Ontario, ... Related articles - All 2 versions
SJ Salpeter, Y Dor - Pancreatic Beta Cell in Health and Disease, 2007 - Springer Summary. Patients suffering from type 1and type 2diabetes exhibit a decrease in the mass of
insulin-producing beta cells. Both the ability to generate and expand large amounts of transplantable
beta cells and the capacity to encour- age beta-cell proliferation in the patient represent ... Related articles - All 2 versions
S Begum, W Chen, KC Herold, VE Papaioannou - Endocrinology, 2009 - Endocrine Soc Type 1 diabetes (T1D) mellitus is characterized by progressive autoimmune destruction of insulin
producing β-cells of the pancreatic islets of Langerhans. Cure of the disease will require control
of autoimmunity to halt the destruction of β-cells in the pancreas and restoration of β-cell ... Related articles - All 3 versions