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Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis


LW Crawford, ET Ables, YA Oh, B Boone, S Levy, M … - PLoS One, 2008 - pubmedcentral.nih.gov
In the past decade, several transcription factors critical for pancreas organogenesis have been
identified. Despite this success, many of the factors necessary for proper islet morphogenesis
and function remain uncharacterized. Previous studies have shown that transgenic over- ...
Cited by 2 - Related articles - All 5 versions

Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell …


LA Crawford, MA Guney, YA Oh, RA DeYoung, … - Molecular …, 2009 - Endocrine Soc
The factors necessary for normal pancreatic islet morphogenesis have not been well
characterized. Here we report that connective tissue growth factor (CTGF) is involved in the establishment
of normal islet endocrine cell ratio and architecture. CTGF is a secreted protein known to ...
Cited by 2 - Related articles - All 3 versions

Pancreas cell fate


MA Guney, M Gannon - Birth defects research. Part C, Embryo …, 2009 - pubmedcentral.nih.gov
Diabetes is characterized by decreased function of insulin-producing insulin β cells and insufficient
insulin output resulting from an absolute (Type 1) or relative (Type 2) inadequate functional β
cell mass. Both forms of the disease would greatly benefit from treatment strategies that ...
Related articles - All 3 versions

Gene Expression Profiling of a Mouse Model of Pancreatic Islet Dysmorphogenesis


L Wilding Crawford, E Tweedie Ables, YA Oh, B Boone, … - PLoS ONE, 2008 - dx.doi.org
In the past decade, several transcription factors critical for pancreas organogenesis have been
identified. Despite this success, many of the factors necessary for proper islet morphogenesis
and function remain uncharacterized. Previous studies have shown that transgenic over- ...


 


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