BA Menge, A Tannapfel, O Belyaev, R Drescher … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Protocol 1: fasting glucose concentrations increased significantly
after the 50% pancreatectomy (P = 0.01), but the fractional β-cell area of the
pancreas remained unchanged (P = 0.11). β-Cell proliferation, the overall ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►nih.gov DA Babu, TG Deering, RG Mirmira - Molecular genetics and metabolism, 2007 - Elsevier Emerging evidence over the past decade indicates a central role for
transcription factors in the embryonic development of pancreatic islets and the
consequent maintenance of normal glucose homeostasis. Pancreatic and ... Cited by 17 - Related articles - All 3 versions
- ►geyseco.info [PDF] JJ Meier - Diabetologia, 2008 - Springer Abstract Beta cell deficiency underlies both type 1 and type 2 diabetes, and
restoration or replacement of beta cell function is therefore the logical
long-term solution to therapy. This review sets out to describe the defects ... Cited by 16 - Related articles - BL Direct - All 6 versions
J Rahier, Y Guiot, RM Goebbels, C Sempoux, … - Diabetes Obes Metab, 2008 - interscience.wiley.com Decreases in both β-cell function and number can contribute to insulin
deficiency in type 2 diabetes. Here, we quantified the β-cell mass in pancreas
obtained at autopsy of 57 type 2 diabetic (T2D) and 52 non-diabetic ... Cited by 10 - Related articles - All 2 versions
AV Matveyenko, PC Butler - Diabetes Obes Metab, 2008 - interscience.wiley.com Regulation of blood glucose concentrations requires an adequate number of
β-cells that respond appropriately to blood glucose levels. β-Cell mass cannot
yet be measured in humans in vivo, necessitating autopsy studies, although ... Cited by 8 - Related articles - All 2 versions
- ►endocrinology-journals.org T Brun, BR Gauthier - Journal of Molecular Endocrinology, 2008 - Soc Endocrinology Blood glucose homeostasis is achieved by the regulation of insulin and glucagon
secretion from the pancreatic islet β- and -cells. Diabetes mellitus, which
comprises a heterogeneous group of hyperglycaemic disorders, results mainly ... Cited by 5 - Related articles - All 4 versions
- ►diabetesjournals.org A Misfeldt… - Diabetes, 2008 - Am Diabetes Assoc RESULTS—In control mice, PPx stimulated β-cell proliferation and neogenesis
and upregulated Foxm1 and several of its known targets (Plk1, Cenp-a,
Birc5/Survivin, and Ccnb1) in islets. Within 1 week post-PPx, control mice ... Cited by 4 - Related articles - All 3 versions
V Koya, S Lu, YP Sun, DL Purich, MA Atkinson … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Restoration of euglycemia in Pdx1-treated diabetic mice was evident by
improved IPGTT and glucose-stimulated insulin release. Insulin, glucagon, and
Ki67 immunostaining revealed increased islet cell number and proliferation ... Cited by 5 - Related articles - BL Direct - All 5 versions
BA Menge, H Schrader, TGK Breuer, Y … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Partial pancreatectomy is frequently per- formed in
patients with pancreatic tumours or chronic pancreatitis, but little is known
about the metabolic impact of this intervention. We examined the effects of ... Cited by 3 - Related articles - All 2 versions
C Bonal, I Avril, P Herrera - Biochemical Society Transactions, 2008 - biochemsoctrans.org The control of glucose metabolism by pancreatic endocrine cells throughout life
relies on a tight regulation of the mass of insulin-producing β-cells. How this
homoeostasis is achieved is not well understood. Over the last few years, ... Cited by 2 - Related articles - Cached - BL Direct - All 4 versions
