- ►cell.com EJP de Koning, S Bonner-Weir, TJ Rabelink - Trends in Pharmacological Sciences, 2008 - Elsevier Type 2 diabetes is characterized by progressive β-cell dysfunction and a
reduction in β-cell mass. Pancreatic islets are a target for adverse effectors
such as high concentrations of glucose, pro-inflammatory cytokines and ... Cited by 14 - Related articles - All 4 versions
KJ Chang-Chen, R Mullur, E Bernal-Mizrachi - Reviews in Endocrine & Metabolic Disorders, 2008 - Springer Abstract Type 2 diabetes mellitus is a complex disease characterized by b-cell
failure in the setting of insulin resistance. In early stages of the disease,
pancreatic b-cells adapt to insulin resistance by increasing mass and ... Cited by 12 - Related articles - All 2 versions
- ►nih.gov T Xie, M Chen, QH Zhang, Z Ma, LS Weinstein - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences The G protein α-subunit G s α is required for hormone-stimulated cAMP
generation. In pancreatic β cells, G s α mediates the signaling of
glucagon-like peptide 1 and other incretin hormones, which are implicated ... Cited by 10 - Related articles - BL Direct - All 6 versions
- ►endojournals.org PT Fueger, JC Schisler, D Lu, DA Babu, RG … - Molecular Endocrinology, 2008 - Endocrine Soc Both major forms of diabetes involve a decline in β-cell mass, mediated by
autoimmune destruction of insulin-producing cells in type 1 diabetes and by
increased rates of apoptosis secondary to metabolic stress in type 2 ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Belmadani, DI Palen, RA Gonzalez- … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— We previously showed epidermal growth factor receptor (EGFR)
transactivation to be key mechanism in the regulation of resistance artery
myogenic tone. Type 2 diabetes is associated with microvascular ... Cited by 6 - Related articles - All 5 versions
P Miettinen, P Ormio, E Hakonen, M Banerjee, … - Biochemical Society Transactions, 2008 - biochemsoctrans.org Pancreatic islet development is impaired in mice lacking EGFRs (epidermal growth
factor receptors). Even partial tissue-specific attenuation of EGFR signalling
in the islets leads to markedly reduced β-cell proliferation and ... Cited by 4 - Related articles - Cached - BL Direct - All 5 versions
MM Ali, FG Agha - Scandinavian Journal of Clinical & Laboratory …, 2009 - informahealthcare.com The effects of various doses of lycopene were studied in streptozotocin
(STZ)‐induced hyperglycaemic rats to evaluate its possible hypoglycaemic,
hypolipidaemic and antioxidant activity in diabetes. Compared to the ... Cited by 2 - Related articles - All 7 versions
S Arnaud-Dabernat, N Sarvetnick - Expert Review of Endocrinology and Metabolism, 2007 - ingentaconnect.com Signaling pathways play critical roles in most physiological and pathological
processes and convert an extracellular stimulus into a change of function in the
recipient cell. Intracellular messages originate from the activation of ... Related articles - All 3 versions
