- ►pnas.org CR Hancock, DH Han, M Chen, S Terada, T … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences It has been hypothesized that insulin resistance is mediated by a deficiency of
mitochondria in skeletal muscle. In keeping with this hypothesis, high-fat diets
that cause insulin resistance have been reported to result in a decrease in ... Cited by 40 - Related articles - BL Direct - All 8 versions
- ►pnas.org SE Wiley, AN Murphy, SA Ross, P van der … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Members of the thiazolidinedione (TZD) class of insulin-sensitizing drugs are
extensively used in the treatment of type 2 diabetes. Pioglitazone, a member of
the TZD family, has been shown to bind specifically to a protein named ... Cited by 37 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org KS Nair, ML Bigelow, YW Asmann, LS Chow, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— The glucose infusion rates required to maintain identical glucose
levels during the similar insulin infusion rates were substantially lower in
diabetic Indians than in the nondiabetic participants (P < 0.001), and they ... Cited by 30 - Related articles - BL Direct - All 4 versions
FGS Toledo, EV Menshikova, K Azuma, Z … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— In obesity and type 2 diabetes, exercise combined with weight loss
increases skeletal muscle mitochondrial capacity. It remains unclear whether
mitochondrial capacity increases because of weight loss, improvements in ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►cnfindpark.cn JO Holloszy - American Journal of Clinical Nutrition, 2009 - Am Soc Nutrition Patients with type 2 diabetes, insulin-resistant obese individuals, and
insulin-resistant offspring of patients with diabetes have 30% less mitochondria
in their skeletal muscles than age-matched healthy controls. It has been ... Cited by 19 - Related articles - All 6 versions
- ►diabetesjournals.org IR Lanza, DK Short, KR Short, S … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— Insulin sensitivity was measured by
hyperinsulinemic-euglycemic clamp and ATP production in mitochondria isolated
from vastus lateralis biopsies of 42 healthy sedentary and ... Cited by 15 - Related articles - All 4 versions
- ►171.66.122.45 M Pravenec, M Hyakukoku, J Houstek, V Zidek, … - Genome Research, 2007 - genome.cshlp.org Recently, the relationship of mitochondrial DNA (mtDNA) variants to metabolic
risk factors for diabetes and other common diseases has begun to attract
increasing attention. However, progress in this area has been limited ... Cited by 14 - Related articles - BL Direct - All 10 versions
N Turner, LK Heilbronn - Trends in Endocrinology & Metabolism, 2008 - Elsevier Insulin resistance is a key defect associated with obesity and type-2 diabetes.
The precise factors that lead to insulin resistance have not been elucidated
fully, but there is a strong association between insulin resistance and ... Cited by 13 - Related articles - All 5 versions
- ►eje.org HM De Feyter, NMA van den Broek, SFE Praet, … - European Journal of Endocrinology, 2008 - eje.org Objective: Several lines of evidence support a potential role of skeletal muscle
mitochondrial dysfunction in the pathogenesis of insulin resistance and/or type
2 diabetes. However, it remains to be established whether mitochondrial ... Cited by 10 - Related articles - BL Direct - All 5 versions
