K Pilgaard, CB Jensen, JH Schou, V Lyssenko, … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis We studied the physiological, metabolic and hormonal
mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2
gene. Methods We undertook genotyping of 81 healthy young Danish men for ... Cited by 6 - Related articles - All 2 versions
- ►physiology.org P Bansal, Q Wang - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Glucose homeostasis is regulated primarily by the opposing actions of insulin
and glucagon, hormones that are secreted by pancreatic islets from β-cells and
-cells, respectively. Insulin secretion is increased in response to ... Cited by 6 - Related articles - All 3 versions
- ►pnas.org H Ellingsgaard, JA Ehses, EB Hammar, L Van … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Interleukin-6 (IL-6) is systemically elevated in obesity and is a predictive
factor to develop type 2 diabetes. Pancreatic islet pathology in type 2 diabetes
is characterized by reduced β-cell function and mass, an increased ... Cited by 6 - Related articles - All 8 versions
- ►physiology.org IH Schulman, MS Zhou, EA Jaimes, L Raij - American Journal of Physiology- Heart and Circulatory …, 2007 - Am Physiological Soc Physiological actions of insulin via activation of the phosphatidylinositol
3-kinase/Akt pathway in the endothelium serve to couple regulation of
hemodynamic and metabolic homeostasis. Insulin resistance, endothelial ... Cited by 8 - Related articles - BL Direct - All 4 versions
A Swali, EA Walker, GG Lavery, JW Tomlinson … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Exposure to excess glucocorticoid is associated with
pancreatic beta cell damage and decreased glucose-stimulated insulin secretion
(GSIS). Inactive glucocorticoids (cortisone, 11-dehydrocorticosterone) are ... Cited by 4 - Related articles - All 2 versions
- ►glucagon.com [PDF] EM Sinclair, B Yusta, C Streutker, LL Baggio, … - Gastroenterology, 2008 - Elsevier Gcgr−/− mice showed enhanced susceptibility to experimental liver injury
induced by either FasL activation or a methionine- and choline-deficient diet.
Restoration of hepatic Gcgr expression in Gcgr−/− mice attenuated the ... Cited by 3 - Related articles - All 47 versions
MS Winzell, CL Brand, N Wierup, UG … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Increased glucagon secretion predicts dete- rioration
of glucose tolerance, and high glucagon levels contribute to hyperglycaemia in
type 2 diabetes. Inhibition of glucagon action may therefore be a potential ... Cited by 2 - Related articles - BL Direct - All 6 versions
- ►physiology.org JA Harney, RL Rodgers - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc At concentrations around 10 –9 M or higher, glucagon increases cardiac
contractility by activating adenylate cyclase/cyclic adenosine monophosphate
(AC/cAMP). However, blood levels in vivo, in rats or humans, rarely exceed ... Cited by 2 - Related articles - All 4 versions
H Yan, W Gu, J Yang, V Bi, Y Shen, E Lee, KA … - Journal of Pharmacology and Experimental …, 2009 - ASPET Antagonizing the glucagon signaling pathway represents an attractive therapeutic
approach for reducing excess hepatic glucose production in patients with type 2
diabetes. Despite extensive efforts, there is currently no human ... Cited by 2 - Related articles - All 4 versions
Y Hayashi, M Yamamoto, H Mizoguchi, C … - Molecular Endocrinology, 2009 - Endocrine Soc Department of Genetics, Division of Stress Adaptation and Recognition (YH, MY,
CW, RI, SY, XS, YM) and Futuristic Environmental Simulation Center (HM),
Research Institute of Environmental Medicine, Nagoya University, 464-8601, ... Related articles
