PJ Oates - Current drug targets, 2008 - ingentaconnect.com Abstract: Aldose reductase (AR) enzymatically transforms cytosolic glucose into
sorbitol, a molecule that poorly pene- trates cell membranes and is sometimes
slowly metabolized. Hyperglycemia can cause intracellular accumulation of ... Cited by 26 - Related articles - BL Direct - All 3 versions
NA Calcutt, CG Jolivalt, P Fernyhough - Current Drug Targets, 2008 - ingentaconnect.com Abstract: There has been a rapid growth in appreciation of the diverse array of
neurotrophic factors, growth factors and other biological molecules that have
the capacity to support adult neurons and direct reparative processes after ... Cited by 9 - Related articles - BL Direct - All 2 versions
AAF Sima - CNS drugs, 2007 - ingentaconnect.com Diabetic polyneuropathy (DPN) is the most common late complication of Abstract
diabetes mellitus. The underlying pathogenesis is multifaceted, with partly
inter- related mechanisms that display a dynamic course. The mechanisms ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►ucsd.edu [PDF] CG Jolivalt, CA Lee, KM Ramos, NA Calcutt - Pain, 2008 - Elsevier Diabetic rats show behavioral indices of painful neuropathy that may model the
human condition. Hyperalgesia during the formalin test in diabetic rats is
accompanied by the apparently paradoxical decrease in spinal release of ... Cited by 8 - Related articles - All 17 versions
- ►wisc.edu [PDF] NA Calcutt, MM Backonja - Current Diabetes Reports, 2007 - Springer Recent advances in understanding the pain associated with diabetic neuropathy
are likely to provide significant mechanistic insights and offer better
therapies. In clini- cal research, new tools for measuring neuropathic pain ... Cited by 6 - Related articles - BL Direct - All 3 versions
AAF Sima, H Kamiya - Current Drug Targets, 2008 - ingentaconnect.com Abstract: In this review we will describe the interaction between insulin and
C-peptide which enhances and attenuates in- sulin-signaling functions. We will
describe how replenishment of C-peptide prevents and reverses the early ... Cited by 5 - Related articles - BL Direct - All 2 versions
F Hayase, H Matsuura, M Sanada, K Kitada- … - Neuroscience letters, 2007 - Elsevier Experimental evidence has been presented to suggest that protein kinase Cβ
isoform-selective inhibitor LY333531 is effective at alleviating diabetic
hyperalgesia. In the present study, we isolated small (≤25 μm in soma ... Cited by 5 - Related articles - All 3 versions
K Sugimoto, IB Rashid, M Shoji, T Suda, M … - Journal of Pain, 2008 - Elsevier The objective of the present study was to evaluate the time course of changes in
peripheral nerve insulin receptor (IR) signaling and compare observed findings
with behavioral responses to noxious mechanical and thermal stimuli in ... Cited by 3 - Related articles - All 27 versions
Z Yang, Z Zhou, X Li, G Huang, J Lin - Diabetes research and clinical practice, 2009 - Elsevier The newly developed insulin sensitizer-thiazolidinediones have the potential to
downregulate inflammation and autoimmune response. The objective of this study
was to observe the beneficial effects on β-cell function in the LADA ... Cited by 2 - Related articles - All 14 versions
AF Anders… - Experimental Diabetes Research, 2008 - hindawi.com Diabetic polyneuropathy (DPN) occurs more frequently in type 1 diabetes
resulting in a more severe DPN. The differences in DPN between the two types of
diabetes are due to differences in the availability of insulin and ... Cited by 2 - Related articles - Cached - All 10 versions
