E Kroon, LA Martinson, K Kadoya, AG Bang, OG … - Nature …, 2008 - novocell.com Development of a cell therapy for diabetes would be greatly aided by a renewable supply of
human ß-cells. Here we show that pancreatic endoderm derived from human embryonic stem
(hES) cells efficiently generates glucose-responsive endocrine cells after implantation ... Cited by 134 - Related articles - View as HTML - BL Direct - All 10 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►pnas.org PA Seymour, KK Freude, MN Tran, EE … - Proceedings of the …, 2007 - National Acad Sciences The factors necessary to maintain organ-specific progenitor cells are poorly understood and
yet of extreme clinical importance. Here, we identify the transcription factor SOX9 as the first specific
marker and maintenance factor of multipotential progenitors during pancreas ... Cited by 53 - Related articles - BL Direct - All 8 versions
- ►cshlp.org MS Gierl, N Karoulias, H Wende, M Strehle, C … - Genes & …, 2006 - genesdev.cshlp.org The pancreatic and intestinal primordia contain epithelial progenitor cells that generate many
cell types. During development, specific programs of gene expression restrict the developmental
potential of such progenitors and promote their differentiation. The Insm1 (insulinoma- ... Cited by 39 - Related articles - BL Direct - All 10 versions
- ►endojournals.org MC Jorgensen, J Ahnfelt-Ronne, J Hald, OD … - Endocrine …, 2007 - Endocrine Soc Pancreas morphogenesis and cell differentiation are highly conserved among vertebrates during
fetal development. The pancreas develops through simple budlike structures on the primitive
gut tube to a highly branched organ containing many specialized cell types. This review ... Cited by 37 - Related articles - BL Direct - All 3 versions
- ►cell.com ST Gangaram-Panday, MM Faas, P de Vos - Trends in Molecular Medicine, 2007 - Elsevier Many approaches of stem-cell therapy for the treatment of diabetes have been described. One
is the application of stem cells for replacement of nonfunctional islet cells in the native endogenous
pancreas; another one is the use of stem cells as an inexhaustible source for islet-cell ... Cited by 31 - Related articles - All 6 versions
- ►nih.gov P Collombat, J Hecksher-Sørensen, J Krull, … - Journal of Clinical …, 2007 - Am Soc Clin Investig Aristaless-related homeobox (Arx) was recently demonstrated to be involved in pancreatic α
cell fate specification while simultaneously repressing the β and δ cell lineages. To establish
whether Arx is not only necessary, but also sufficient to instruct the α cell fate in endocrine ... Cited by 26 - Related articles - BL Direct - All 6 versions
I Artner, B Blanchi, JC Raum, M Guo, T … - Proceedings of the …, 2007 - National Acad Sciences Pancreatic endocrine cell differentiation depends on transcription factors that also contribute
in adult insulin and glucagon gene expression. Islet cell development was examined in mice
lacking MafB, a transcription factor expressed in immature α (glucagon + ) and β (insulin + ... Cited by 21 - Related articles - BL Direct - All 7 versions
- ►pubget.com [PDF] JC Raum, K Gerrish, I Artner, E Henderson, M … - Molecular and cellular …, 2006 - Am Soc Microbiol The MafA transcription factor is both critical to islet ß-cell function and has a unique pancreatic
cell-type-specific expression pattern. To localize the potential transcriptional regulatory
region(s) involved in directing expression to the ß cell, areas of identity within the 5' ... Cited by 21 - Related articles - BL Direct - All 5 versions
JM Oliver-Krasinski, DA Stoffers - Genes & development, 2008 - genesdev.cshlp.org The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and decreased
β-cell numbers, raising hope for cell replacement therapy. Although human islet transplantation
is a cell-based therapy under clinical investigation for the treatment of type 1 diabetes, the ... Cited by 21 - Related articles - All 4 versions
