- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org AM Ackermann, M Gannon - Journal of molecular endocrinology, 2007 - Soc Endocrinology Pancreatic ß-cells are responsible for producing all of the insulin required by
an organism to maintain glucose homeostasis. Defects in development,
maintenance, or expansion of ß-cell mass can result in impaired glucose ... Cited by 37 - Related articles - All 4 versions
R Mussmann, M Geese, F Harder, S Kegel, U … - Journal of Biological Chemistry, 2007 - ASBMB Recent developments indicate that the regeneration of beta cell function and
mass in patients with diabetes is possible. A regenerative approach may
represent an alternative treatment option relative to current diabetes ... Cited by 30 - Related articles - All 7 versions
LC Alonso, T Yokoe, P Zhang, DK Scott, SK … - Diabetes, 2007 - Am Diabetes Assoc Developing new techniques to induce β-cells to replicate is a major goal in
diabetes research. Endogenous β-cells replicate in response to metabolic
changes, such as obesity and pregnancy, which increase insulin requirement. ... Cited by 28 - Related articles - BL Direct - All 5 versions
M Peshavaria, BL Larmie, J Lausier, B Satish, … - Diabetes, 2006 - Am Diabetes Assoc The pancreatic β-cell has a substantial capacity to functionally compensate in
response to physiological and pathophysiological changes in tissue insulin
requirements. A fundamental aspect of this response is the dynamic ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►jbc.org K Fulzele, DJ DiGirolamo, Z Liu, J Xu, JL … - Journal of Biological Chemistry, 2007 - ASBMB Defective bone formation is common in patients with diabetes, suggesting that
insulin normally exerts anabolic actions in bone. However, because insulin can
cross-activate the insulin-like growth factor type 1 receptor (IGF-1R), ... Cited by 15 - Related articles - All 4 versions
- ►endojournals.org JL Beith, EU Alejandro, JD Johnson - Endocrinology, 2008 - Endocrine Soc A relative decrease in β-cell mass is key in the pathogenesis of type 1
diabetes, type 2 diabetes, and in the failure of transplanted islet grafts. It
is now clear that β-cell duplication plays a dominant role in the ... Cited by 13 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org RC Vasavada, I Cozar-Castellano, D Sipula, … - Diabetes, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D-cyclins, cdk-4, p18, p21,
p27) are critical for normal regulation of β-cell proliferation, mass, and
function. The retinoblastoma protein, pRb, is positioned at the very end of ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►fasebj.org J Chen, ST Hui, FM Couto, IN Mungrue, DB … - The FASEB Journal, 2008 - FASEB Pancreatic beta-cell loss through apoptosis represents a key factor in the
pathogenesis of diabetes; however, no effective approaches to block this process
and preserve endogenous beta-cell mass are currently available. To study ... Cited by 11 - Related articles - All 5 versions
- ►diabetesjournals.org I Cozar-Castellano, M Haught, AF Stewart - Diabetes, 2006 - Am Diabetes Assoc The rate of pancreatic β-cell replication is extremely slow. For example,
Finegood et al. (1) report that 3% of rodent β-cells replicate every 24 h.
Kushner and colleagues (2) have recently reported that in older mice, this ... Cited by 11 - Related articles - BL Direct - All 5 versions
