- ►physiology.org R Muniyappa, S Lee, H Chen, MJ Quon - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Insulin resistance contributes to the pathophysiology of diabetes and is a
hallmark of obesity, metabolic syndrome, and many cardiovascular diseases.
Therefore, quantifying insulin sensitivity/resistance in humans and animal ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►endojournals.org NM Thompson, AM Norman, SS Donkin, RR … - Endocrinology, 2007 - Endocrine Soc Obesity and type 2 diabetes are worldwide health issues. The present paper
investigates prenatal and postnatal pathways to obesity, identifying different
metabolic outcomes with different effects on insulin sensitivity and ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►physiology.org BM De Taeye, T Novitskaya, OP McGuinness, … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc Obesity is commonly associated with development of insulin resistance and
systemic evidence of inflammation. Macrophages contribute to inflammatory
amplification in obesity and may contribute directly to insulin resistance ... Cited by 23 - Related articles - BL Direct - All 4 versions
- ►shouxi.net JE Ayala, DP Bracy, BM Julien, JN Rottman, … - Diabetes, 2007 - Am Diabetes Assoc Stimulation of nitric oxide–cGMP signaling results in vascular relaxation and
increased muscle glucose uptake. We show that chronically inhibiting cGMP
hydrolysis with the phosphodiesterase-5 inhibitor sildenafil improves ... Cited by 23 - Related articles - BL Direct - All 5 versions
R Rao, CM Hao, R Redha, DH Wasserman, … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis In the current study, the effect of a highly specific
peptide inhibitor of glycogen synthase kinase 3 (GSK3) (L803-mts) on glucose
metabolism and BP was examined in a high-fat (HF) fed mouse model of ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►physiology.org S Lee, R Muniyappa, X Yan, H Chen, LQ Yue … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Insulin resistance contributes to the pathophysiology of diabetes, obesity, and
their cardiovascular complications. Mouse models of these human diseases are
useful for gaining insight into pathophysiological mechanisms. The ... Cited by 16 - Related articles - BL Direct - All 3 versions
- ►physiology.org … , DH Wasserman, OP McGuinness, IR Sweet, … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Islets in most species respond to increased glucose with biphasic insulin
secretion, marked by a sharp first-phase peak and a slowly rising second phase.
Mouse islets in vitro, however, lack a robust second phase. To date, this ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►glucagon.com [PDF] JE Ayala, DP Bracy, T Hansotia, G Flock, Y … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Compared with wild-type mice, chow and high fat–fed DIRKO mice
exhibited decreased fat and muscle mass associated with increased energy
expenditure and ambulatory activity. Clamp rates of glucose infusion (GIR), ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org ED Berglund, CY Li, G Poffenberger, JE … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Insulin action and hypoglycemic counter-regulatory and insulin
secretory phenotypes varied considerably in four inbred mouse strains. In vivo
insulin secretion was greatest in 129X1/Sv mice, but the counter-regulatory ... Cited by 8 - Related articles - All 5 versions
- ►glucagon.com [PDF] JE Ayala, DP Bracy, FD James, BM Julien, … - Endocrinology, 2009 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) diminishes postmeal glucose excursions by
enhancing insulin secretion via activation of the β-cell GLP-1 receptor
(Glp1r). GLP-1 may also control glucose levels through mechanisms that are ... Cited by 6 - Related articles - All 4 versions
