AT Hattersley, ER Pearson - Endocrinology, 2006 - Endocrine Soc Defining the molecular genetics of diabetes gives new insight into the underlying etiology and
so should help improve treatment. The genetic etiology is now known for most patients with
ß-cell monogenic diabetes, allowing genetic classification. We review how this genetic ... Cited by 43 - Related articles - BL Direct - All 8 versions
F Shojaee-Moradie, KCR Baynes, C Pentecost, JD Bell … - Diabetologia, 2007 - Springer Page 1. ARTICLE Exercise training reduces fatty acid availability and improves the insulin
sensitivity of glucose metabolism F. Shojaee-Moradie & KCR Baynes & C. Pentecost & JD Bell
& EL Thomas & NC Jackson & M. Stolinski & M. Whyte & D. Lovell & SB Bowes & ... Cited by 23 - Related articles - BL Direct - All 5 versions
AL Gloyn, S Ellard - Expert Opin. Pharmacother., 2006 - informahealthcare.com A molecular genetic diagnosis is now possible for > 80% of patients with monogenic
diabetes. This not only provides accurate information regarding inheritance and prognosis, but
can inform treatment decisions and improve clinical outcome. Mild fasting ... Cited by 11 - Related articles - BL Direct - All 6 versions
J Skupien, MT Malecki, W Mlynarski, T … - The Review of …, 2006 - pubmedcentral.nih.gov Activating mutations in the KCNJ11 gene encoding the Kir6.2 subunit of ATP-sensitive potassium
channel have been described in patients with permanent neonatal diabetes mellitus
(PNDM). The main pathophysiological feature of PNDM associated with Kir6.2 mutations ... Cited by 7 - Related articles - All 3 versions
K Pilgaard, CB Jensen, JH Schou, V Lyssenko, L … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis We studied the physiological, metabolic and hormonal mechanisms
underlying the elevated risk of type 2 diabetes in carriers of TCF7L2 gene. Methods We undertook
genotyping of 81 healthy young Danish men for rs7903146 of TCF7L2 and carried out ... Cited by 6 - Related articles - All 2 versions
- ►endojournals.org R Murphy, J Baptista, J Holly, AM Umpleby, S … - Journal of Clinical …, 2008 - Endocrine Soc Context: IGF-II is an imprinted gene (predominantly transcribed from the paternally inherited
allele), which has an important role in fetal growth in mice. IGF2 gene expression is regulated
by a complex system of enhancers and promoters that determine tissue-specific and ... Cited by 5 - Related articles - All 3 versions
M van de Bunt, AL Gloyn - Personalized Medicine, 2007 - Future Medicine Over the past 10–20 years, our understanding of the genetic etiology of monogenic disorders
of the pancreatic β-cell has greatly improved. This has enabled clinicians to provide patients
with more accurate information regarding prognosis and inheritance and has influenced ... Cited by 1 - Related articles - BL Direct - All 3 versions
S Kitanaka - Expert Review of Endocrinology and Metabolism, 2008 - ingentaconnect.com Hepatocyte nuclear factor (HNF)-1α and HNF-1β are transcription factors that regulate many
target genes in various tissues including liver, pancreas and kidney. Heterozygous mutations
in the HNF-1α and HNF-1β genes result in maturity-onset diabetes of the young (MODY)3 ... Related articles
ER Pearson - Diabetologia, 2009 - Springer We are living through a revolution in genetics research. At present, barely a week goes by without
a flurry of reports revealing robustly replicated loci associating with a common complex
disease. Diabetes was one of the first disease areas to yield results from these genome- ... Cited by 1 - Related articles - All 2 versions
