P Marchetti, M Bugliani, R Lupi, L Marselli, M Masini, U … - Diabetologia, 2007 - Springer Page 1. ARTICLE The endoplasmic reticulum in pancreatic beta cells of type 2
diabetes patients P. Marchetti & M. Bugliani & R. Lupi & L. Marselli & M. Masini &
U. Boggi & F. Filipponi & GC Weir & DL Eizirik & M. Cnop Received ... Cited by 47 - Related articles - BL Direct - All 2 versions
- ►rupress.org M Ohara-Imaizumi, T Fujiwara, Y Nakamichi, T … - Journal of Cell …, 2007 - jcb.rupress.org The mechanism of glucose-induced biphasic insulin release is unknown. We used total internal
reflection fluorescence (TIRF) imaging analysis to reveal the process of first- and second-phase
insulin exocytosis in pancreatic ß cells. This analysis showed that previously docked ... Cited by 30 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org EP Kwan, L Xie, L Sheu, CJ Nolan, M Prentki, A Betz, N … - Diabetes, 2006 - Am Diabetes Assoc Munc13-1 is a diacylglycerol (DAG) receptor that is essential for synaptic vesicle priming. We
recently showed that Munc13-1 is expressed in rodent and human islet β-cells and that its levels
are reduced in islets of type 2 diabetic humans and rat models, suggesting that Munc13-1 ... Cited by 21 - Related articles - All 5 versions
- ►endojournals.org M Dubois, P Vacher, B Roger, D Huyghe, B … - Endocrinology, 2007 - Endocrine Soc Prolonged exposure of ß-cells to high glucose (glucotoxicity) diminishes insulin secretion in response
to glucose and has been linked to altered generation of metabolism-secretion coupling
factors. We have investigated whether glucotoxicity may also alter calcium handling and ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►shouxi.net EP Kwan, L Xie, L Sheu, T Ohtsuka, HY Gaisano - Diabetes, 2007 - Am Diabetes Assoc RESULTS—To determine which exocytotic steps caused by Munc13-1 deficiency are rescued
by Epac2 and PKA, we used patch-clamp capacitance measurements, showing that 1) cAMP
restored the reduced readily releasable pool (RRP) and partially restored refilling of a ... Cited by 16 - Related articles - BL Direct - All 4 versions
P Marchetti, F Dotta, D Lauro, F Purrello - Regulatory Peptides, 2008 - Elsevier Type 2 diabetes is the most common form of diabetes in humans. It results from a combination
of factors that impair beta-cell function and tissue insulin sensitivity. However, growing evidence
is showing that the beta-cell is central to the development and progression of this form of ... Cited by 16 - Related articles - All 3 versions
PE MacDonald, P Rorsman - Physiology (Bethesda, Md.), 2007 - ncbi.nlm.nih.gov Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance
of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release
their contents and are subsequently recaptured either intact or through conventional ... Cited by 13 - Related articles - BL Direct - All 4 versions
P Lovis, S Gattesco, R Regazzi - Biological Chemistry, 2008 - reference-global.com Fine-tuning of insulin secretion from pancreatic b-cells participates in blood glucose
homeostasis. Defects in this process can lead to chronic hyperglycemia and dia- betes
mellitus. Several proteins controlling insulin exo- cytosis have been identified, but the ... Cited by 13 - Related articles - BL Direct - All 3 versions
- ►pnas.org AF Jeans, PL Oliver, R Johnson, M … - Proceedings of the …, 2007 - National Acad Sciences The neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptor
(SNARE) complex is essential for synaptic vesicle exocytosis, but its study has been limited by
the neonatal lethality of murine SNARE knockouts. Here, we describe a viable mouse line ... Cited by 13 - Related articles - BL Direct - All 9 versions
- ►mcponline.org H Lu, Y Yang, EM Allister, N Wijesekara, MB … - Molecular & Cellular …, 2008 - ASBMB Type 2 diabetes (T2D) arises when pancreatic β-cells fail to compensate for systemic insulin
resistance with appropriate insulin secretion. However, the link between insulin resistance and
β-cell failure in T2D is not fully understood. To explore this association, we studied ... Cited by 11 - Related articles - All 7 versions
