S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc The prevalence of diabetes mellitus is growing rapidly. It is estimated that globally the number
of adults affected with diabetes will increase from 135 million in 1995 to 300 million by 2025.
1 Patients with diabetes mellitus are at increased risk for cardiovascular diseases. Thus, ... Cited by 140 - Related articles - All 5 versions
D An, B Rodrigues - American Journal of Physiology- Heart and …, 2006 - Am Physiological Soc In patients with diabetes, an increased risk of symptomatic heart failure usually develops in the
presence of hypertension or ischemic heart disease. However, a predisposition to heart failure
might also reflect the effects of underlying abnormalities in diastolic function that can ... Cited by 67 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org H Ashrafian, MP Frenneaux, LH Opie - Circulation, 2007 - Am Heart Assoc Although neurohumoral antagonism has successfully reduced heart failure morbidity and
mortality, the residual disability and death rate remains unacceptably high. Though abnormalities
of myocardial metabolism are associated with heart failure, recent data suggest that heart ... Cited by 66 - Related articles - All 5 versions
- ►diabetesjournals.org S Boudina, S Sena, H Theobald, X Sheng, JJ Wright, … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—db/db hearts exhibited reduced cardiac function and increased MVo 2 . Mitochondrial
reactive oxygen species (ROS) generation and lipid and protein peroxidation products were
increased. Mitochondrial proliferation was increased in db/db hearts, oxidative ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org JG Duncan, JL Fong, DM Medeiros, BN Finck, DP Kelly - Circulation, 2007 - Am Heart Assoc Methods and Results— Morphometric analyses demonstrated that cardiac myocyte mitochondrial
volume density was increased in insulin-resistant uncoupling protein-diptheria toxin A
(UCP-DTA) transgenic mice, a murine model of metabolic syndrome, compared with ... Cited by 42 - Related articles - All 4 versions
- ►physiology.org S Boudina, ED Abel - Physiology, 2006 - Am Physiological Soc Diabetes is a worldwide epidemic (112). Cardiovascular disease remains the major cause of
morbidity and mortality in people with diabetes. Epidemiological studies suggest that the prevalence
of heart failure exceeds that which can be accounted for by other risk factors such as ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org W Hsueh, ED Abel, JL Breslow, N Maeda, RC … - Circulation …, 2007 - Am Heart Assoc From the Division of Endocrinology, Diabetes, and Hypertension (WH), and Department of
Medicine, Division of Cardiology (RCD), The David Geffen School of Medicine, University of
California, Los Angeles; Division of Endocrinology, Metabolism, and Diabetes (EDA and ... Cited by 39 - Related articles - All 6 versions
- ►onlinejacc.org RM Witteles, MB Fowler - Journal of the American College of Cardiology, 2008 - Elsevier Increasing evidence points to insulin resistance as a primary etiologic factor in the development
of nonischemic heart failure (HF). The myocardium normally responds to injury by altering substrate
metabolism to increase energy efficiency. Insulin resistance prevents this adaptive ... Cited by 39 - Related articles - All 25 versions
JW Calvert, S Gundewar, S Jha, JJM Greer, WH … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Clinical studies have reported that metformin reduces cardiovascular end points
of type 2 diabetic subjects by actions that cannot solely be attributed to glucose-lowering
effects. The therapeutic effects of metformin have been reported to be mediated by its ... Cited by 31 - Related articles - BL Direct - All 4 versions
ED Abel, SE Litwin, G Sweeney - Physiological Reviews, 2008 - Am Physiological Soc The dramatic increase in the prevalence of obesity and its strong association with cardiovascular
disease have resulted in unprecedented interest in understanding the effects of obesity on the
cardiovascular system. A consistent, but puzzling clinical observation is that obesity ... Cited by 25 - Related articles - BL Direct - All 3 versions
