- ►nih.gov JMM Howson, DB Dunger, S Nutland, H … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302,
and allelic variation of the T cell regulatory gene cytotoxic
T-lymphocyte-associated antigen-4 (CTLA4) and of the T cell activation gene ... Cited by 24 - Related articles - BL Direct - All 8 versions
- ►nih.gov Z Chen, J Stockton, D Mathis, C Benoist - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences The CTLA4 gene is important for T lymphocyte-mediated immunoregulation and has
been associated with several autoimmune diseases, in particular, type 1
diabetes. To model the impact of natural genetic variants of CTLA4, we ... Cited by 18 - Related articles - BL Direct - All 9 versions
- ►jimmunol.org K Hunter, D Rainbow, V Plagnol, JA Todd, LB … - The Journal of Immunology, 2007 - Am Assoc Immnol Two loci, Idd5.1 and Idd5.2, that determine susceptibility to type 1 diabetes
(T1D) in the NOD mouse are on chromosome 1. Idd5.1 is likely accounted for by a
synonymous single nucleotide polymorphism in exon 2 of Ctla4: the ... Cited by 10 - Related articles - All 3 versions
AA Chentoufi, NR Binder, N Berka, T Abunadi … - Scandinavian Journal of Immunology, 2008 - interscience.wiley.com Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of
insulin-producing pancreatic β cells by autoreactive T cells. The polygenic
trait for T1D risk implicates many genes that have an impact on fundamental ... Cited by 3 - Related articles - BL Direct - All 4 versions
JA Shizuru - Thomas' Hematopoietic Cell Transplantation. Malden, …, 2004 - blackwellpublishing.com Autoimmune diseases (ADs) are a heterogeneous group of disorders that affect an
estimated 3–5% of the population [1,2]. These diseases occur when there is
breakdown in the signals that mediate immune tolerance to normal tissues. ... Cited by 3 - Related articles - All 5 versions
DS Brown - GSBS Dissertations, 2005 - escholarship.umassmed.edu Page 1. Graduate School of Biomedical Sciences GSBS Dissertations University of
Massachusetts Medical School Year 2005 CD4+ T Cell Responses: A Complex ... Related articles - All 2 versions
P Gao, Y Jiao, Q Xiong, CY Wang, I Gerling, … - Current Genomics, 2008 - pubmedcentral.nih.gov A systematic study has been conducted of all available reports in PubMed and
OMIM (Online Mendelian Inheritance in Man) to examine the genetic and molecular
basis of quantitative genetic loci (QTL) of diabetes with the main focus on ... Related articles - All 4 versions
M Lundholm - umu.diva-portal.org Type 1 Diabetes (T1D) is an autoimmune disorder caused by both genetic and
environmental factors. The non-obese diabetic (NOD) mouse is one of the best and
most commonly studied animal models for T1D. This mouse strain ... Related articles - View as HTML