EO Gracheva, AO Burdina, AM Holgado, M … - PLoS Biol, 2006 - biology.plosjournals.org Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding
protein implicated in the modulation of both constitutive and regulated exocytosis. To investigate
how TOM-1 regulates exocytosis of synaptic vesicles in vivo, we analyzed C. elegans ... Cited by 28 - Related articles - Cached - All 10 versions
U Becherer, J Rettig - Cell and tissue research, 2006 - Springer Abstract The release of neurotransmitter from synaptic vesicles represents the final event by
which presynapses send their chemical signal to the receiving postsynapses. Prior to fusion,
synaptic vesicles undergo a series of maturation events, most notably the membrane- ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►shouxi.net EP Kwan, L Xie, L Sheu, T Ohtsuka, HY Gaisano - Diabetes, 2007 - Am Diabetes Assoc RESULTS—To determine which exocytotic steps caused by Munc13-1 deficiency are rescued
by Epac2 and PKA, we used patch-clamp capacitance measurements, showing that 1) cAMP
restored the reduced readily releasable pool (RRP) and partially restored refilling of a ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►endojournals.org YM Leung, EP Kwan, B Ng, Y Kang, HY Gaisano - Endocrine reviews, 2007 - Endocrine Soc The three SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor)
proteins, syntaxin, SNAP25 (synaptosome-associated protein of 25 kDa), and
synaptobrevin, constitute the minimal machinery for exocytosis in secretory cells such as ... Cited by 16 - Related articles - BL Direct - All 3 versions
- ►cjb.net EO Gracheva, AO Burdina, D Touroutine, M … - Journal of …, 2007 - neuro.cjb.net The syntaxin-interacting protein tomosyn is thought to be a key regulator of exocytosis, although
its precise mechanism of action has yet to be elucidated. Here we examined the role of tomosyn
in peptide secretion in Caenorhabditis elegans tomosyn (tom-1) mutants. Ultrastructural ... Cited by 10 - Related articles - All 4 versions
O Yizhar, N Lipstein, SE Gladycheva, U … - Journal of …, 2007 - interscience.wiley.com Tomosyn is a cytoplasmic protein that was shown to bind to Syntaxin1 and SNAP-25 through
an R-SNARE domain, forming a complex that is almost identical in structure to the neuronal SNARE
complex. Tomosyn inhibits exocytosis in various cell types and these effects were ... Cited by 8 - Related articles - BL Direct - All 3 versions
- ►physoc.org EO Gracheva, AO Burdina, D Touroutine, M … - The Journal of …, 2007 - Physiological Soc The SNARE proteins, syntaxin, SNAP-25 and synaptobrevin form a tertiary complex essential
for vesicle fusion. Proteins that influence SNARE complex assembly are therefore likely to be
important regulators of fusion events. In this study we have focused on tomosyn, a highly ... Cited by 5 - Related articles - BL Direct - All 6 versions
- ►jbc.org SE Gladycheva, AD Lam, J Liu, M D'Andrea- … - Journal of Biological …, 2007 - ASBMB Tomosyn, a soluble R-SNARE protein identified as a binding partner of the Q-SNARE syntaxin
1A, is thought to be critical in setting the level of fusion-competent SNARE complexes for
neurosecretion. To date, there has been no direct evaluation of the dynamics in which ... Cited by 6 - Related articles - All 6 versions
EP Kwan, HY Gaisano - Diabetes Obes Metab, 2007 - interscience.wiley.com Exocytosis of insulin vesicles in the pancreatic β-cell involves a sequence of regulated
events, whose normal function and efficient adaptation to increased demand are essential for
the maintenance of glucose homeostasis. These exocytotic events comprise the ... Cited by 4 - Related articles - All 2 versions
O Yizhar, U Ashery - PLoS One, 2008 - pubmedcentral.nih.gov In neurons and neuroendocrine cells, docked vesicles need to undergo priming to become fusion
competent. Priming is a multi-step process that was shown to be associated with vesicle
immobilization. However, it is not known whether vesicle immobilization is sufficient to ... Cited by 4 - Related articles - All 6 versions
