- ►jbc.org T Uchida, N Iwashita, M Ohara-Imaizumi, T … - Journal of Biological Chemistry, 2007 - ASBMB Protein kinase C (PKC) is considered to modulate glucose-stimulated insulin
secretion. Pancreatic cells express multiple isoforms of PKCs; however, the role
of each isoform in glucose-stimulated insulin secretion remains ... Cited by 12 - Related articles - All 6 versions
- ►rupress.org T Rose, S Efendic, M Rupnik - Journal of General Physiology, 2007 - jgp.rupress.org The Goto Kakizaki (GK) rat is a widely used animal model to study defective
glucose-stimulated insulin release in type-2 diabetes (T2D). As in T2D patients,
the expression of several proteins involved in Ca 2+ -dependent exocytosis ... Cited by 10 - Related articles - BL Direct - All 5 versions
RC Vasavada, L Wang, Y Fujinaka, KK Takane, … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE— Diabetes results from a deficiency of functional β-cells. Previous
studies have identified hepatocyte growth factor (HGF) and parathyroid
hormone–related protein (PTHrP) as two potent β-cell mitogens. The ... Cited by 7 - Related articles - BL Direct - All 3 versions
- ►uc.pt [PDF] E Nunes, F Peixoto, T Louro, CM Sena, MS … - Acta Diabetologica, 2007 - Springer Abstract We investigated the effect of sub-chronic soy- bean oil (SO) treatment
on the insulin secretion and fatty acid composition of islets of Langerhans
obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and nor- mal ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org H Ghanaat-Pour, Z Huang, M Lehtihet, A … - Journal of molecular endocrinology, 2007 - Soc Endocrinology The spontaneously diabetic Goto-Kakizaki (GK) rat is frequently used as a model
for human type 2 diabetes. Selective loss of glucose-sensitive insulin secretion
is an early pathogenetic event in human type 2 diabetes, and such a defect ... Cited by 6 - Related articles - All 3 versions
- ►nih.gov C Schmitz-Peiffer, TJ Biden - Diabetes, 2008 - Am Diabetes Assoc Increased lipid availability is strongly associated with both β-cell
dysfunction and insulin resistance, two key facets of type 2 diabetes. Isoforms
of the protein kinase C (PKC) family have been viewed as candidates for ... Cited by 5 - Related articles - All 4 versions
- ►jhc.org M Oyasu, M Fujimiya, K Kashiwagi, S Ohmori, … - Journal of Histochemistry and Cytochemistry, 2008 - Histochemical Soc PROTEIN KINASE C (PKC) consists of a family of serine/threonine kinases that
plays crucial roles in the signal transduction pathways of virtually all cell
types (Nishizuka 1988 Go ,1992 Go ). More than 10 different PKC subtypes ... Cited by 3 - Related articles - BL Direct - All 4 versions
CG Ostenson, S Efendic - Diabetes Obes Metab - interscience.wiley.com Defective β-cell function with resulting impairment of glucose-stimulated
insulin release is a critical factor in the pathogenesis of type 2 diabetes.
Accumulated studies in pancreatic islets of the spontaneously diabetic Goto- ... Cited by 3 - Related articles - All 2 versions
N Warwar, A Dov, E Abramovitch, R Wu, M … - BBA-Molecular Cell Research, 2008 - Elsevier Endocrine cells produce large amounts of one or more peptides. The
post-translational control of selective production of a single protein is often
unknown. We used 3 unrelated approaches to diminish PKCε in rat islets to ... Cited by 1 - Related articles - All 2 versions
EN Churchill, N Qvit, D Mochly-Rosen - Trends in Endocrinology & Metabolism, 2009 - Elsevier Protein–protein interactions sequester enzymes close to their substrates.
Protein kinase C (PKC) is one example of a ubiquitous signaling molecule with
effects that are dependent upon localization. Short peptides derived from ... Cited by 1 - Related articles - All 6 versions
