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Scholar Results 1 - 10 of about 23 citing Michael: Pancreatic β-cells secrete insulin in fast-and slow-release forms. (0.14 sec) 

Biogenesis of secretory granules

- cam.ac.uk [PDF] 
B Borgonovo, J Ouwendijk, M Solimena - Current opinion in cell biology, 2006 - Elsevier
Since their discovery by electron microscopy more than fifty years ago,
secretory granules (SGs, also known as large dense core vesicles) of
neuroendocrine cells have attracted the attention of cell biologists. This ...
Cited by 17 - Related articles - All 5 versions

Orchestration of glucose homeostasis

- shouxi.net
RN Bergman - Diabetes, 2007 - Am Diabetes Assoc
Type 2 diabetes is increasing at alarming rates in the US, in Westernized
countries, and in the third world. The increasing costs in terms of human
suffering as well as economics are well recognized (1). Improved ...
Cited by 16 - Related articles - BL Direct - All 9 versions

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo-and …


PE MacDonald, P Rorsman - Physiology (Bethesda, Md.), 2007 - ncbi.nlm.nih.gov
Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is
crucial to maintenance of plasma glucose levels. They fuse with the plasma
membrane in a regulated manner to release their contents and are ...
Cited by 13 - Related articles - BL Direct - All 4 versions

Mechanisms of peptide hormone secretion

- cell.com
DJ Michael, H Cai, W Xiong, J Ouyang, RH … - Trends in Endocrinology & Metabolism, 2006 - Elsevier
According to the classical view, peptide hormones are stored in large dense-core
vesicles that release all of their cargo rapidly and completely when they fuse
with and flatten into the plasma membrane. However, recent imaging studies ...
Cited by 13 - Related articles - All 4 versions

Two-photon excitation imaging of exocytosis and endocytosis and determination of their …


H Kasai, T Kishimoto, T Nemoto, H … - Advanced drug delivery reviews, 2006 - Elsevier
Two-photon excitation imaging is the least invasive optical approach to study
living tissues. We have established two-photon extracellular polar-tracer (TEP)
imaging with which it is possible to visualize and quantify all exocytic ...
Cited by 12 - Related articles - All 5 versions

Human insulin vesicle dynamics during pulsatile secretion

- diabetesjournals.org
DJ Michael, W Xiong, X Geng, P Drain, RH … - Diabetes, 2007 - Am Diabetes Assoc
In healthy individuals, plasma insulin levels oscillate in both fasting and fed
states. Numerous studies of isolated pancreata and pancreatic islets support the
hypothesis that insulin oscillations arise because the underlying rate of ...
Cited by 8 - Related articles - BL Direct - All 5 versions

Single-cell microelectrochemistry


A Schulte, W Schuhmann - ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN …, 2007 - interscience.wiley.com
Needle-type voltammetric ultramicroelectrodes show exceptional sensitivity for
the detection of redox-active substances, rapid response times, and total tip
diameters in the lower micrometer range. These characteristics make them ...
Cited by 7 - Related articles - BL Direct - All 3 versions

Identifying the targets of the amplifying pathway for insulin secretion in pancreatic β-cells …

- nih.gov
Y Chen, S Wang, A Sherman - Biophysical Journal, 2008 - Elsevier
A kinetic model for insulin secretion in pancreatic β-cells is adapted from a
model for fast exocytosis in chromaffin cells. The fusion of primed granules
with the plasma membrane is assumed to occur only in the “microdomain” ...
Cited by 3 - Related articles - All 5 versions

Banting Lecture 2006

- solvingdiabetes.org [PDF] 
RN Bergman - Diabetes, 2007 - Am Diabetes Assoc
T ype 2 diabetes is increasing at alarming rates in the US, in Westernized
countries, and in the third world. The increasing costs in terms of human
suffering as well as economics are well recognized (1). Improved ...
Cited by 2 - Related articles - All 2 versions

Beta cell chromogranin B is partially segregated in distinct granules and can be released …


T Giordano, C Brigatti, P Podini, E Bonifacio, … - Diabetologia, 2008 - Springer
Abstract Aims/hypothesis We investigated, in three beta cell lines (INS-1E,
RIN-5AH, betaTC3) and in human and rodent primary beta cells, the storage and
release of chromogranin B, a secretory protein expressed in beta cells and ...
Cited by 2 - Related articles - BL Direct - All 2 versions


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