S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc The prevalence of diabetes mellitus is growing rapidly. It is estimated that globally the number
of adults affected with diabetes will increase from 135 million in 1995 to 300 million by 2025.
1 Patients with diabetes mellitus are at increased risk for cardiovascular diseases. Thus, ... Cited by 140 - Related articles - All 5 versions
SM Davidson, MR Duchen - Cell Calcium, 2006 - Elsevier The phenomenon of calcium microdomains is firmly established in the field of subcellular
physiology. These regions of localized, transient calcium increase are exemplified by the spontaneous
'sparks' released through the ryanodine receptor in myocytes, but include ... Cited by 23 - Related articles - All 3 versions
- ►physiology.org H Cheng, WJ Lederer - Physiological reviews, 2008 - Am Physiological Soc The calcium ion (Ca 2+ ) is the simplest and most versatile intracellular messenger known. The
discovery of Ca 2+ sparks and a related family of elementary Ca 2+ signaling events has revealed
fundamental principles of the Ca 2+ signaling system. A newly appreciated "digital" ... Cited by 21 - Related articles - All 3 versions
- ►physiology.org P Yue, T Arai, M Terashima, AY Sheikh, F … - American Journal of …, 2007 - Am Physiological Soc The db/db mouse is a well-established model of diabetes. Previous reports have documented
contractile dysfunction (ie, cardiomyopathy) in these animals, although the extant literature provides
limited insights into cardiac structure and function as they change over time. To better ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►physiology.org JD Huber, RL VanGilder, KA Houser - American Journal of …, 2006 - Am Physiological Soc This study investigated the effects of streptozotocin-induced diabetes on the functional integrity
of the blood-brain barrier in the rat at 7, 28, 56, and 90 days, using vascular space markers ranging
in size from 342 to 65,000 Da. We also examined the effect of insulin treatment of ... Cited by 17 - Related articles - BL Direct - All 4 versions
- ►physiology.org N Fulop, MM Mason, K Dutta, P Wang, AJ … - American Journal of …, 2007 - Am Physiological Soc Increased levels of O-linked attachment of N-acetylglucosamine (O-GlcNAc) on nucleocytoplasmic
proteins are implicated in the development of diabetic cardiomyopathy and are regulated by
O-GlcNAc transferase (OGT) expression and its substrate UDP-GlcNAc. Therefore, the ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►physiology.org VA Lacombe, S Viatchenko-Karpinski, D … - American Journal of …, 2007 - Am Physiological Soc Isolated diastolic dysfunction is found in almost half of asymptomatic patients with well-controlled
diabetes and may precede diastolic heart failure. However, mechanisms that underlie diastolic
dysfunction during diabetes are not well understood. We tested the hypothesis that ... Cited by 10 - Related articles - All 4 versions
CH Shao, GJ Rozanski, KP Patel, KR Bidasee - Journal of molecular and …, 2007 - Elsevier Using biochemical/pharmacological approaches, we previously showed that type 2 ryanodine
receptors (RyR2) become dysfunctional in hearts of streptozotocin-induced type 1 diabetic
rats. However, the functional consequence of this observation remains incompletely ... Cited by 9 - Related articles - All 15 versions
- ►endocrinology-journals.org Z Li, T Zhang, H Dai, G Liu, H Wang, Y Sun, … - Journal of …, 2008 - Soc Endocrinology Apoptosis plays a critical role in the diabetic cardiomyopathy, and endoplasmic reticulum stress
(ERS) is one of the intrinsic apoptosis pathways. Previous studies have shown that the endoplasmic
reticulum becomes swollen and dilated in diabetic myocardium, and ERS is involved in ... Cited by 9 - Related articles - BL Direct - All 4 versions
