P Libby, J Plutzky - The American Journal of Cardiology, 2007 - Elsevier Patients with type 2 diabetes mellitus and/or the metabolic syndrome have considerable cardiovascular
risk. Treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) and
with antihypertensive and some antihyperglycemic agents reduces this risk, but residual ... Cited by 60 - Related articles - All 32 versions
- ►ahajournals.org SZ Duan, MG Usher, RM Mortensen - Circulation Research, 2008 - Am Heart Assoc Peroxisome proliferator-activated receptor (PPAR)- is a nuclear receptor and transcription factor
in the steroid superfamily. PPAR- agonists, the thiazolidinediones, are clinically used to treat
type 2 diabetes. In addition to its function in adipogenesis and increasing insulin ... Cited by 45 - Related articles - All 5 versions
- ►ahajournals.org CP Liang, S Han, T Senokuchi, AR Tall - Circulation research, 2007 - Am Heart Assoc The macrophage has emerged as an important player in the pathogenesis of both atherosclerosis
and insulin resistance. Cross-talk between inflammatory macrophages and adipocytes may be
involved in insulin resistance in peripheral tissues. Defective insulin signaling in cells of ... Cited by 43 - Related articles - All 6 versions
- ►ahajournals.org JE Kanter, F Johansson, RC LeBoeuf, KE … - Circulation research, 2007 - Am Heart Assoc It is becoming increasingly clear that suboptimal blood glucose control results in adverse effects
on large blood vessels, thereby accelerating atherosclerosis and cardiovascular disease, manifested
as myocardial infarction, stroke, and peripheral vascular disease. Cardiovascular disease ... Cited by 33 - Related articles - All 8 versions
- ►ahajournals.org R Marfella, M Siniscalchi, M Portoghese, C Di Filippo, F … - Hypertension, 2007 - Am Heart Assoc Whether morning blood pressure surge influences the molecular mechanisms of plaque progression
toward instability is not known. Recently, we have demonstrated enhanced activity of the
ubiquitin–proteasome system in human plaques and evidenced that it is associated with ... Cited by 25 - Related articles - All 5 versions
- ►ahajournals.org J Xu, Y Wu, P Song, M Zhang, S Wang, MH Zou - Circulation, 2007 - Am Heart Assoc Methods and Results— Exposure of human umbilical vein endothelial cells to high glucose concentrations
(30 mmol/L D-glucose) but not to high osmotic conditions (25 mmol/L L-glucose plus 5
mmol/L D-glucose) significantly lowered the levels of both GTPCH protein and BH4. In ... Cited by 21 - Related articles - All 5 versions
C Di Filippo, S Cuzzocrea, F Rossi, R … - Cardiovascular drug …, 2006 - interscience.wiley.com The risk factors, such as hypertension and metabolic syndrome, tend to promote heart
pathology. These risk factors can aggravate concomitant heart insults as well. Diabetes mellitus
represents one of the most important risk factors for the development of heart pathology. ... Cited by 19 - Related articles - BL Direct - All 4 versions
K Nagao, T Yanagita - Progress in Lipid Research, 2008 - Elsevier The metabolic syndrome is a cluster of metabolic disorders, such as abdominal obesity,
dyslipidemia, hypertension and impaired fasting glucose that contribute to increased cardiovascular
morbidity and mortality. Although the pathogenesis of metabolic syndrome is complicated ... Cited by 16 - Related articles - All 4 versions
BE Sobel - The American Journal of Medicine, 2007 - Elsevier This article presents a series of take-home statements, compiled by a multidisciplinary steering
committee, concerning significant aspects of macrovascular disease in patients with diabetes
mellitus, including the extent of risk, pathogenetic mechanisms, and optimal management ... Cited by 14 - Related articles - All 12 versions
J Karalliedde, RE Buckingham - Drug Safety, 2007 - ingentaconnect.com Thiazolidinediones (TZDs) or glitazones are agents that are widely used for the Abstract treatment
of type 2 diabetes mellitus. These drugs have a multitude of therapeutic effects including reduction
in insulin resistance and hyperglycaemia, anti-inflam- matory effects and amelioration of ... Cited by 15 - Related articles - BL Direct - All 6 versions
