- ►cell.com JK Howard, JS Flier - Trends in Endocrinology & Metabolism, 2006 - Elsevier Leptin and insulin are key hormones involved in the regulation of energy balance and glucose
homeostasis. Development of resistance to the action of these hormones, which can occur with
age, obesity and inflammation, appears to have a prime role in the pathogenesis of ... Cited by 69 - Related articles - All 12 versions
- ►endojournals.org J Jager, T Grémeaux, M Cormont, Y Le Marchand- … - Endocrinology, 2007 - Endocrine Soc Inflammation is associated with obesity and insulin resistance. Proinflammatory cytokines produced
by adipose tissue in obesity could alter insulin signaling and action. Recent studies have shown
a relationship between IL-1ß level and metabolic syndrome or type 2 diabetes. However, ... Cited by 53 - Related articles - BL Direct - All 8 versions
WP Cawthorn, JK Sethi - FEBS letters, 2008 - Elsevier Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic
conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such
as obesity-related type 2 diabetes). Two common features of these metabolic disorders ... Cited by 40 - Related articles - All 12 versions
- ►ebmonline.org M Endo, T Masaki, M Seike, H Yoshimatsu - Experimental Biology and Medicine, 2007 - SEBM We investigated the effect of tumor necrosis factor- (TNF- ), a member of the proinflammatory
cytokine family, on steatosis of the mouse liver by analyzing morphological changes and hepatic
triglyceride content in response to TNF- . We also examined expression of the sterol ... Cited by 17 - Related articles - BL Direct - All 4 versions
Y Kanatani, I Usui, K Ishizuka, A Bukhari, S Fujisaka, M … - Diabetes, 2007 - Am Diabetes Assoc Pioglitazone is widely used for the treatment of diabetic patients with insulin resistance. The mechanism
of pioglitazone to improve insulin sensitivity is not fully understood. Recent studies have shown
that the induction of suppressor of cytokine signaling 3 (SOCS3) is related to the ... Cited by 14 - Related articles - BL Direct - All 6 versions
ER Kallwitz, A McLachlan, SJ Cotler - World Journal of …, 2008 - pubmedcentral.nih.gov An estimated 30% of adults and 10% of children and adolescents in the United States have nonalcoholic
fatty liver disease (NAFLD), defined as liver fat content exceeding 5% (Figure 1)[ 1 – 3 ].
Non-alcoholic fatty liver disease is associated with obesity, non-insulin dependent ... Cited by 14 - Related articles - BL Direct - All 7 versions
- ►jneurosci.org NS Singhal, MA Lazar, RS Ahima - Journal of Neuroscience, 2007 - Soc Neuroscience Sensing of peripheral hormones and nutrients by the hypothalamus plays an important role in
maintaining peripheral glucose homeostasis. The hormone resistin impairs the response to insulin
in liver and other peripheral tissues. Here we demonstrate that in normal mice resistin ... Cited by 11 - Related articles - All 3 versions
M Koulmanda, E Budo, S Bonner-Weir, A … - Proceedings of the …, 2007 - National Acad Sciences In nonobese diabetic (NOD) mice with overt new-onset type 1 diabetes mellitus (T1DM),
short-term treatment with a “triple-therapy” regimen [rapamycin plus agonist IL-2-related and
antagonist-type, mutant IL-15-related Ig fusion proteins (IL-2.Ig and mutIL-15.Ig)] halts ... Cited by 13 - Related articles - BL Direct - All 8 versions
P Lebrun, E Van Obberghen - Acta Physiologica, 2008 - interscience.wiley.com First discovered as inhibitors of cytokine signalling, the suppressor of cytokine signalling
(SOCS) proteins have appeared, over recent years, as potent repressors of other signalling pathways
including the one induced by insulin. SOCS-1 and SOCS-3 have been extensively ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►endojournals.org [PDF] J Jager, T Grémeaux, M Cormont, Y Le Marchand- … - Endocrinology, 2006 - Endocrine Soc Page 1. - 1 - INTERLEUKIN-1β−INDUCED INSULIN RESISTANCE IN ADIPOCYTES THROUGH
DOWN-REGULATION OF IRS-1 EXPRESSION Running Title: IL-1β and insulin resistance Jennifer
Jager, Thierry Grémeaux, Mireille Cormont , Yannick Le Marchand-Brustel, and ... Cited by 6 - Related articles - All 2 versions
